Y. Han

Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing

This paper introduces DRAM, a method for transcriptome-wide m5C detection using deaminase and reader proteins, showing high overlap with BS-seq data and supporting low-input RNA.

TRPML1 gating modulation by allosteric mutations and lipids

This study identifies allosteric mutations and lipid interactions that modulate TRPML1 channel function, revealing structural insights into its regulation by lipids and potential therapeutic targets.

The Hippo pathway effector YAP inhibits NF-kB signaling and ccRCC growth by opposing ZHX2

This study shows YAP inhibits NF-κB signaling and ccRCC growth by blocking ZHX2, a co-factor of NF-κB, and competes with ZHX2 for binding to p65.

The silicon transporters (SITs) gene was found in Synechococcus sp. XM24

This study identifies and characterizes potential silicon transporters (SITs) in Synechococcus sp. XM24 under silicate-depleted conditions.

SMARCA4 mutation induces tumor cell-intrinsic defects in enhancer landscape and resistance to immunotherapy

This study shows that SMARCA4 mutations in lung cancer disrupt enhancer landscapes and innate immune gene expression, leading to immunotherapy resistance.

Viral diversiy within marine biofilms and their potential roles in microbially influenced corrosion

This study analyzes viral communities in marine biofilms on 8 materials to explore their roles in microbially influenced corrosion, finding viruses influence corrosion through interactions with corrosive microbes.

Cold seeps are hotspots of deep-sea nitrogen-loss driven by microorganisms across 21 phyla

This study identifies cold seeps as significant nitrogen-loss hotspots, revealing diverse microbial communities and active nitrogen-loss genes across multiple phyla.

ApoE ε4-dependent alteration of CXCR3+CD127+ CD4+ T cells is associated with elevated plasma neurofilament light chain in Alzheimer's disease

The paper finds that ApoE ε4-dependent changes in CXCR3+CD127+ CD4+ T cells in peripheral blood correlate with elevated neurofilament light chain in Alzheimer's disease.

Silicification of Cyanobacteria

This study compares silicification mechanisms in cyanobacteria and diatoms, finding similar proteins but suggesting cyanobacteria may have an earlier but less efficient silicon accumulation mechanism.

Evolutionary analysis of paired box gene family and biological function exploration of Lr.Pax7 in lamprey (Lethenteron reissneri)

This study identifies and analyzes Pax7 in lamprey, showing its potential ancestral role and functional similarities to higher vertebrates in metabolic and developmental processes.

FKBP11 targeted plasma cells promote abdominal aortic aneurysm progression through an m6A-dependent mechanism

This study identifies FKBP11's role in AAA progression via m6A-dependent mechanisms using multi-omics and machine learning.

Innate liking and disgust reactions elicited by intraoral capsaicin in male mice

This study shows that capsaicin induces liking and disgust reactions in male mice through orofacial and bodily responses, similar to taste reactivity.

Circular DNA vcDNA-S7 derived from segmented-dsRNA virus BmCPV attenuated viral infection through RNase H1

The paper identifies a novel antiviral mechanism where vcDNA-S7, derived from BmCPV, recruits RNase H1 to degrade viral RNA through heteroduplex formation, thereby suppressing viral replication.

A Ratiometric Catalog of Protein Isoform Shifts in the Cardiac Fetal Gene Program

The paper identifies widespread isoform usage shifts in fetal and postnatal mouse hearts using proteome-wide ratio quantification, revealing novel isoform switches and evolutionary patterns.

Structural basis for Retriever-SNX17 assembly and endosomal sorting

This study determines the structure of the Retriever-SNX17 complex using cryo-EM, revealing how SNX17 interacts with Retriever to facilitate endosomal sorting of cargo proteins.

Discovery of the First-in-class G9a/GLP PROTAC Degrader

This paper discovers a first-in-class PROTAC degrader for G9a/GLP, showing effective degradation and superior anticancer activity compared to existing inhibitors.

Reductive dehalogenation by diverse microbes is central to biogeochemical cycles in deep-sea cold seeps

The paper investigates reductive dehalogenation in deep-sea cold seeps, identifying diverse RDases and their ecological role in biogeochemical cycles.

A high-fidelity in vitro model of the human intestinal epithelium

This paper develops an in vitro model of the human intestinal epithelium that closely mimics in vivo cell types using single-cell transcriptomics and a biomedical foundation model.

Mapping adipocyte interactome networks by HaloTag enrichment mass-spectrometry

The paper introduces HaloMS, a high-throughput method for mapping protein interactions in adipocytes, identifying new transcription factor complexes and networks.

Integrated Hfq-interacting RNAome and transcriptomic analysis reveals complex regulatory networks of nitrogen fixation in root-associated Pseudomonas stutzeri A1501

This study identifies Hfq-binding RNAs in Pseudomonas stutzeri A1501 using eCLIP-seq, revealing new regulatory targets involved in nitrogen fixation and other metabolic processes.

Mechanism of connexin channel inhibition by mefloquine and 2-aminoethoxydiphenyl borate

The paper identifies two distinct binding sites for connexin channel inhibitors mefloquine and 2APB, showing they block channel function through different mechanisms.

pan-MHC and cross-Species Prediction of T Cell Receptor-Antigen Binding

This paper develops pMTnet-omni, an AI system predicting TCR-pMHC binding across species and MHC classes, achieving high accuracy and showing clinical utility in predicting immune-related adverse events.

Berberine impairs spermatogenesis in mice by modulating ornithine metabolism via gut microbiota regulation

This study shows berberine reduces sperm count and testosterone in mice by altering gut microbiota, specifically reducing Muribaculaceae, and affecting ornithine metabolism.

MiceVAPORDot: A novel automated approach for high-throughput behavioral characterization during E-cigarette exposure in mice

MiceVAPORDot automates behavioral analysis during e-cigarette exposure in mice, revealing phenotypes not detectable by traditional methods.

Drug Discovery in Low Data Regimes: Leveraging a Computational Pipeline for the Discovery of Novel SARS-CoV-2 Nsp14-MTase Inhibitors

This paper introduces a computational pipeline for identifying SARS-CoV-2 nsp14 inhibitors using virtual screening, identifying seven candidates including NSC620333 and SS148, with experimental validation of binding affinity and structural insights.

A vast repertoire of secondary metabolites influences community dynamics and biogeochemical processes in cold seeps

This study investigates secondary metabolites in cold seep microbiomes using metagenomic, metatranscriptomic, and metabolomic data, revealing diverse biosynthetic gene clusters and their potential ecological roles.

Percutaneous Intramyocardial Septal Cryoablation: A Canine Model with 6 months Follow-up

This study establishes a canine model for echocardiography-guided percutaneous intramyocardial septal cryoablation and shows its safety and feasibility in reducing interventricular septum.

Multi-color live-cell optical nanoscopy using phasor analysis

This paper introduces a method to enable multicolor live-cell STED imaging with at least 4 colors using phasor analysis to separate dyes of the same spectrum.

Nuclear Localization of Argonaute is affected by Cell Density and May Relieve Repression by microRNAs

This study shows that nuclear localization of AGO2 in HCT116 cells and human colon tumors can de-repress miRNA targets and enhance cell migration, influenced by cell density, miRNA biogenesis, and miRISC components.

Comprehensive Characterization and Global Transcriptome Analyses of Human Fetal Liver Terminal Erythropoiesis

This study characterizes human fetal liver terminal erythropoiesis through RNA sequencing of primary and cultured erythroblasts and immortalized cell lines, revealing gene expression patterns and pathway changes associated with enucleation.