Tumors attenuating the mitochondrial activity in T cells escape from PD-1 blockade therapy
T. Honjo, A. Kumar, K. Chamoto, P. S. Chowdhury
This study identifies two mechanisms of resistance to PD-1 blockade therapy in tumors: one involving systemic immunosuppressive molecules that inhibit T cell mitochondrial activity, and another through loss of MHC class I expression.
bioRxiv · Oct 21, 2019Immunology