A universal pocket in FAALs ensures redirection of fatty acid pool away from CoA-based activation
G. S. Patil, P. Kinatukara, S. Mondal, S. Shambhavi, K. D. Patel, S. Pramanik, N. Dubey, S. Narasimhan, M. K. Madduri, B. Pal, R. S. Gokhale, R. Sankaranarayanan
The paper identifies a unique binding pocket in FAALs that allows them to selectively use holo-ACP over CoA, enabling CoA-independent fatty acid activation and lipid biosynthesis.
bioRxiv · May 4, 2021Biochemistry