Author

S. Narasimhan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1

Frequent Co-Authors

E. Fikrig· 2 shared I. Kaverina· 2 shared U. Pal· 2 shared A. J. O'Neal· 1 shared A. Marin-Lopez· 1 shared A. Primessnig· 1 shared A. Rolandelli· 1 shared A. Sajid· 1 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersImmunology

E. Fikrig

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Merging of ventral fibers at adhesions drives the remodeling of cellular contractile systems in fibroblasts.

S. Narasimhan, W. R. Holmes, I. Kaverina

The paper identifies VSF merging as a mechanism for aligning long contractile fibers in fibroblasts, driven by mechanical forces and adhesion dynamics.

bioRxiv · Mar 16, 2022Cell Biology

CD36 homologs determine microbial resistance to the Lyme disease spirochete

A. J. O'Neal, N. Singh, I. S. Forrest, A. Rolandelli, X. Wang, D. K. Shaw, B. D. Young, S. Narasimhan, S. Dutta, G. A. Snyder, L. Marnin, L. R. Butler, S. Samaddar, M. T. Mendes, F. E. C. Paz, , J. H. F. Pedra

The paper identifies CD36 homologs as conserved lipid receptors mediating anti-Borrelia immunity in both ticks and humans.

bioRxiv · Feb 9, 2022 · PreprintImmunology

The Lyme Disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector

X. Tang, y. cao, G. Arora, J. Hwang, A. Sajid, C. Brown, S. Mehta, A. Marin-Lopez, Y.-M. Chuang, M.-J. Wu, H. Ma, U. Pal, S. Narasimhan, E. Fikrig

This study identifies a tick metabolic pathway involving ISARL that Borrelia burgdorferi exploits to establish infection, suggesting a mechanism for manipulating host metabolism.

bioRxiv · Sep 13, 2021Microbiology

A universal pocket in FAALs ensures redirection of fatty acid pool away from CoA-based activation

G. S. Patil, P. Kinatukara, S. Mondal, S. Shambhavi, K. D. Patel, S. Pramanik, N. Dubey, S. Narasimhan, M. K. Madduri, B. Pal, R. S. Gokhale, R. Sankaranarayanan

The paper identifies a unique binding pocket in FAALs that allows them to selectively use holo-ACP over CoA, enabling CoA-independent fatty acid activation and lipid biosynthesis.

bioRxiv · May 4, 2021Biochemistry

A Focal Adhesion Filament Cross-correlation Kit for fast, automated segmentation and correlation of focal adhesions and actin stress fibers in cells

L. Hauke, S. Narasimhan, A. Primessnig, I. Kaverina, F. Rehfeldt

This paper introduces FAFCK, a tool for automated analysis of focal adhesions and actin stress fibers, enabling correlation studies to improve mechanocellular force analysis.

bioRxiv · Apr 14, 2021Biophysics