AMPK-dependent phosphorylation is required for transcriptional activation of TFEB/TFE3
M. Paquette, L. El-Houjeiri, L. C. Zirden, P. Puustinen, P. Blanchette, H. Jeong, K. Dejgaard, P. M. Siegel, A. Pause
This study shows that AMPK-dependent phosphorylation of TFEB/TFE3 enhances their transcriptional activity under nutrient starvation and promotes chemoresistance in cancer.
bioRxiv · Jan 27, 2021Cancer Biology