Author

A. Pause

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Organism:C. elegans· 1

Frequent Co-Authors

L. El-Houjeiri· 3 shared M. Paquette· 3 shared H. Jeong· 2 shared J. M. Kazan· 2 shared P. Blanchette· 2 shared P. M. Siegel· 2 shared A. Kania· 1 shared A. Klar· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCancer Biology

L. El-Houjeiri

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

AMPK-dependent phosphorylation is required for transcriptional activation of TFEB/TFE3

M. Paquette, L. El-Houjeiri, L. C. Zirden, P. Puustinen, P. Blanchette, H. Jeong, K. Dejgaard, P. M. Siegel, A. Pause

This study shows that AMPK-dependent phosphorylation of TFEB/TFE3 enhances their transcriptional activity under nutrient starvation and promotes chemoresistance in cancer.

bioRxiv · Jan 27, 2021Cancer Biology

FLCN Gene Ablation Reduces Fibrosis and Inflammation in a Diet-Induced NASH Model

M. Paquette, M. Yan, L. El-Houjeiri, M. Biondini, J. M. J. Ramirez-Reyes, A. Pacis, H. Jeong, J. L. Estall, P. M. Siegel, A. Pause

This study shows that FLCN gene ablation reduces fibrosis and inflammation in a diet-induced NASH model by enhancing autophagy and lysosomal biogenesis.

bioRxiv · Sep 10, 2020 · PreprintPathology

The transcription factors TFEB and TFE3 link the FLCN-AMPK signaling axis to innate immune response and pathogen resistance

L. El-Houjeiri, E. Possik, T. Tarika Vijayaraghavan, M. Paquette, J. A. Martina, J. M. Kazan, E. H. Ma, R. Jones, P. Blanchette, R. Puertollano, A. Pause

This study identifies a conserved mechanism linking FLCN-AMPK signaling to TFEB/TFE3 activation, enhancing innate immunity and pathogen resistance across species.

bioRxiv · Nov 6, 2018Immunology

The endosomal sorting adaptor HD-PTP is required for ephrin-B:EphB signalling in cell collapse and motor axon guidance

S. Lahaie, D. Morales, H. Bagci, N. Hamoud, C.-E. Castonguay, J. M. Kazan, G. Desrochers, A. Klar, A.-C. Gingras, A. Pause, J.-F. Cote, A. Kania

This study identifies HD-PTP as an ESCRT adaptor required for ephrin-B:EphB signalling, affecting cell collapse and axon guidance by modulating receptor clustering and degradation.

bioRxiv · Aug 7, 2018Cell Biology