The mechanism underlying transient weakness in myotonia congenita
M. M. Rich, J. H. Myers, K. Denman, C. DuPont, A. A. Hawash, K. R. Novak, A. Koesters, M. Grabner, A. Dayal, A. A. Voss
This study identifies plateau potentials caused by Na+ and Ca2+ currents in Becker disease models and shows that inhibiting NaPIC with ranolazine prevents transient weakness.
bioRxiv · Dec 23, 2020Physiology