Mucosal delivery of a multistage subunit vaccine promotes development of lung-resident memory T cells and affords interleukin-17-dependant protection against pulmonary tuberculosis
C. Counoupas, K. Ferrell, A. Ashhurst, N. D. Bhattacharyya, G. Nagalingam, C. G. Feng, N. Petrovsky, W. J. Britton, J. A. Triccas
This paper shows that a mucosal vaccine induces lung-resident memory T cells expressing IL-17, which protect against tuberculosis, and that IL-17 is critical for this protection.
bioRxiv · Feb 25, 2020 · PreprintImmunology