Author

A. Ashhurst

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:CITE-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Aggarwal· 3 shared R. J. Payne· 3 shared S. G. Turville· 3 shared J. A. Triccas· 2 shared M. Larance· 2 shared T. Passioura· 2 shared A. Drelich· 1 shared A. Norman· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersBiochemistry

A. Aggarwal

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Discovery of Antiviral Cyclic Peptides Targeting the Main Protease of SARS-CoV-2 via mRNA Display

J. Johansen-Leete, S. Ullrich, S. Fry, R. Frkic, M. Bedding, A. Aggarwal, A. Ashhurst, K. Ekanayake, M. Mahawaththa, V. Sasi, T. Passioura, M. Larance, G. Otting, S. G. Turville, C. J. Jackson, , R. J. Payne

This study identifies cyclic peptides targeting SARS-CoV-2 main protease using mRNA display, showing antiviral activity in vitro.

bioRxiv · Aug 23, 2021Biochemistry

Discovery of Cyclic Peptide Ligands to the SARS-CoV-2 Spike Protein using mRNA Display

A. Norman, C. Franck, M. Christie, P. Hawkins, K. Patel, A. Ashhurst, A. Aggarwal, J. K. Low, R. Siddiquee, C. Ashley, M. Steain, J. A. Triccas, S. G. Turville, J. Mackay, T. Passioura, R. J. Payne

The paper identifies cyclic peptide ligands to the SARS-CoV-2 spike protein RBD using mRNA display, finding six high-affinity molecules with nanomolar dissociation constants.

ACS Central Science · Jun 23, 2021Peer-reviewedBiochemistry

Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L

A. Ashhurst, A. Tang, P. Fajtova, M. Yoon, A. Aggarwal, A. Stoye, M. Larance, L. Beretta, A. Drelich, D. Skinner, L. Li, T. Meek, J. McKerrow, V. Hook, C.-T. Tseng, , R. J. Payne

bioRxiv · Dec 23, 2020 · PreprintBiochemistry

Mucosal delivery of a multistage subunit vaccine promotes development of lung-resident memory T cells and affords interleukin-17-dependant protection against pulmonary tuberculosis

C. Counoupas, K. Ferrell, A. Ashhurst, N. D. Bhattacharyya, G. Nagalingam, C. G. Feng, N. Petrovsky, W. J. Britton, J. A. Triccas

This paper shows that a mucosal vaccine induces lung-resident memory T cells expressing IL-17, which protect against tuberculosis, and that IL-17 is critical for this protection.

bioRxiv · Feb 25, 2020 · PreprintImmunology