K. Guillemin

A mucin-regulated adhesin determines the intestinal biogeography and inflammatory character of a bacterial symbiont.

This study identifies a mucin-binding adhesin that regulates bacterial colonization and inflammation in the gut by sensing mucin-associated glycans.

Disaggregation as an interaction mechanism among intestinal bacteria

This study shows that bacterial species in the zebrafish gut compete by dissolving aggregates, and multi-species communities can stabilize this interaction.

Secreted Aeromonas GlcNAc binding protein GbpA stimulates epithelial cell proliferation in the zebrafish intestine

This study identifies a secreted Aeromonas protein, GbpA, that stimulates intestinal epithelial cell proliferation in zebrafish, suggesting a role in host-bacterial coexistence.

Enteric nervous system modulation of luminal pH modifies the microbial environment to promote intestinal health

This study shows that the enteric nervous system regulates luminal pH, which influences microbial composition and intestinal inflammation in zebrafish.

The immunomodulatory dCache chemoreceptor TlpA of Helicobacter pylori binds multiple attractant and antagonistic ligands via distinct sites

This study identifies multiple ligands bound by the H. pylori chemoreceptor TlpA, revealing both attractant and antagonist functions through distinct binding sites.

Pseudocapillaria tomentosa, Mycoplasma spp., and intestinal lesions in experimentally infected zebrafish Danio rerio

This study investigates the role of Mycoplasma spp. and Pseudocapillaria tomentosa in causing intestinal lesions and neoplasms in zebrafish through experimental infections.

A bacterial inflammation sensor regulates c-di-GMP signaling, adhesion, and biofilm formation.

This paper identifies a bacterial sensor that detects HOCl, a host-derived oxidant, and links its activation to biofilm formation through a redox-sensitive zinc-cysteine switch.

Identification and characterization of zebrafish Tlr4 co-receptor Md-2

The paper identifies a zebrafish Md-2 homolog, ly96, and shows it forms a Tlr4a complex that activates NF-κB in response to LPS, suggesting an ancestral Tlr4/Md-2 system in vertebrates.

Swimming motility and chemotaxis control the spatial organization, persistence, and inflammatory activity of a model intestinal pathobiont

This study shows that swimming motility and chemotaxis in Vibrio bacteria control their spatial organization, persistence, and inflammatory activity in the zebrafish gut.

Sublethal antibiotics collapse gut bacterial populations by enhancing aggregation and expulsion

The paper shows sublethal antibiotics reduce gut bacterial abundance by promoting aggregation and expulsion in zebrafish larvae.

Agent-Based Modeling Demonstrates How Local Chemotactic Behavior Can Shape Biofilm Architecture

The paper uses agent-based modeling to show that local chemotactic behavior of H. pylori cells toward AI-2 can explain the global architecture of biofilms.

Bacterial cohesion predicts spatial distribution in the larval zebrafish intestine

The paper shows that bacterial cohesion in zebrafish intestines correlates with their spatial distribution, suggesting general biophysical rules govern microbiome organization.