Facilitation of hERG channels by blockers: a mechanism predicted to reduce lethal cardiac arrhythmias
K. Furutani, K. Tsumoto, I.-S. Chen, K. Handa, Y. Yamakawa, J. T. Sack, Y. Kurachi
This paper proposes that hERG channel facilitation by blockers can reduce lethal cardiac arrhythmias by preventing early afterdepolarizations during repolarization.
bioRxiv · Jun 8, 2018Pharmacology & Toxicology