Author

I.-S. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:electrophysiology· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:Xenopus· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Y. Kubo· 2 shared C. LIU· 1 shared D. Fedida· 1 shared J. Eldstrom· 1 shared J. T. Sack· 1 shared K. Furutani· 1 shared K. Handa· 1 shared K. Tsumoto· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiophysics

Y. Kubo

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural determinants of the direct inhibition of GIRK channels by Sigma-1 receptor antagonist

C. LIU, I.-S. Chen, M. Tateyama, Y. Kubo

This study identifies BD1047 as a direct inhibitor of GIRK channels, showing stronger inhibition of GIRK4 than GIRK2 and revealing structural determinants involving Leu77 on GIRK4.

bioRxiv · Nov 7, 2023Biophysics

A novel ion conducting route besides the central pore in an inherited mutant of G-protein-gated inwardly rectifying K+ channel

I.-S. Chen, J. Eldstrom, D. Fedida, Y. Kubo

This study identifies a novel ion-conducting pathway in a GIRK channel mutant, showing it allows Li+ permeation independent of the selectivity filter.

The Journal of Physiology · Dec 29, 2021Peer-reviewedPhysiology

Facilitation of hERG channels by blockers: a mechanism predicted to reduce lethal cardiac arrhythmias

K. Furutani, K. Tsumoto, I.-S. Chen, K. Handa, Y. Yamakawa, J. T. Sack, Y. Kurachi

This paper proposes that hERG channel facilitation by blockers can reduce lethal cardiac arrhythmias by preventing early afterdepolarizations during repolarization.

bioRxiv · Jun 8, 2018Pharmacology & Toxicology