Author

K. J. Lauersen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 6 Biochemistry· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:proteomics· 5 Organism:C. elegans· 4 Assay:metabolomics· 3 Research Focus:protein folding & dynamics· 3 Research Focus:drug response / drug discovery· 2 Organism:plant (other)· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

B. Bastos de Freitas· 3 shared S. Overmans· 3 shared G. B. Wellman· 2 shared S. J. Overmans· 2 shared A. AlJahdali· 1 shared A. K. Beke· 1 shared B. C. B. de Freitas· 1 shared C. Cheng· 1 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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3 shared papersBioengineering

B. Bastos de Freitas

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Comparison of alternative solvents for in situ extraction of hydrocarbons from the colonial green alga Botryococcus braunii race B (Showa)

T. A. Ozawa-Uyeda, S. J. Overmans, B. Bastos de Freitas, E. Lozoya-Gloria, K. J. Lauersen

This paper compares 15 solvents for in situ extraction of hydrocarbons from Botryococcus braunii, finding that bio-based terpenes recover more hydrocarbons than alkanes, but all tested solvents were toxic to the algae.

bioRxiv · Oct 23, 2023 · PreprintBiochemistry

Engineered ketocarotenoid biosynthesis in the polyextremophilic red microalga Cyanidioschyzon merolae 10D

M. Seger, F. Mammadova, M. Villegas-Valencia, B. Bastos de Freitas, C. Cheng, I. Isachsen, H. Hemstreet, F. Abualsaud, M. Boring, P. J. Lammers, K. J. Lauersen

This paper demonstrates the successful engineering of ketocarotenoid biosynthesis in the red microalga C. merolae 10D using heterologous enzymes, enabling simultaneous production of phycocyanin and ketocarotenoids.

bioRxiv · Feb 27, 2023 · PreprintBioengineering

Cultivation of the polyextremophile Cyanidioschyzon merolae 10D during summer conditions on the coast of the Red Sea and its adaptation to hypersaline sea water

M. V. Villegas, R. E. Gonzalez-Portela, B. Bastos de Freitas, A. AlJahdali, G. I. Romero-Villegas, R. Abdulsalam, R. V. Kapoore, C. Fuentes-Grunewald, K. J. Lauersen

This study cultivates Cyanidioschyzon merolae 10D under Red Sea summer conditions, showing its adaptability to high salinity and stable biomass composition.

bioRxiv · Feb 2, 2023 · PreprintBioengineering

Engineered production of isoprene from the model green microalga Chlamydomonas reinhardtii

R. Z. Yahya, G. B. Wellman, S. Overmans, K. J. Lauersen

This paper reports the first heterologous isoprene production from a eukaryotic alga by engineering Chlamydomonas reinhardtii to express plant isoprene synthases and optimize metabolic pathways.

bioRxiv · Jan 12, 2023Bioengineering

Biomass generation and heterologous isoprenoid milking from engineered microalgae grown in anaerobic membrane bioreactor effluent

B. C. B. de Freitas, S. Overmans, J. S. Medina, P.-Y. Hong, K. J. Lauersen

This paper demonstrates the use of engineered Chlamydomonas reinhardtii to generate biomass and high-value isoprenoids directly from anaerobic membrane bioreactor effluent.

bioRxiv · Sep 29, 2022Bioengineering

Continuous extraction and concentration of secreted metabolites from engineered microbes using membrane technology

S. J. Overmans, G. Ignacz, A. K. Beke, J. Xu, P. Saikaly, G. Szekely, K. J. Lauersen

This paper develops a membrane-based method to extract and concentrate patchoulol from engineered microalgae, achieving lower solvent use and economic sustainability compared to existing methods.

bioRxiv · Mar 10, 2022Bioengineering

Combinatorial engineering for photoautotrophic production of recombinant products from the green microalga Chlamydomonas reinhardtii

M. N. Abdallah, G. B. Wellman, S. Overmans, K. J. Lauersen

This study engineers Chlamydomonas reinhardtii to produce recombinant products under non-sterile conditions using combinatorial chloroplast and nuclear genome modifications.

bioRxiv · Feb 28, 2022Bioengineering

Turning a green alga red: engineering astaxanthin biosynthesis by intragenic pseudogene revival in Chlamydomonas reinhardtii.

F. Perozeni, S. Cazzaniga, T. Baier, F. Zanoni, G. Zoccatelli, K. J. Lauersen, L. Wobbe, M. Ballottari

This paper engineers Chlamydomonas reinhardtii to overexpress a modified β-carotene ketolase, enabling astaxanthin biosynthesis and achieving competitive pigment productivity.

bioRxiv · Jan 31, 2019Plant Biology