C. Cheng

Does Sex-Differential Gene Expression Drive Sex-Differential Selection in Humans?

The paper challenges the hypothesis that sex-differential gene expression drives sex-differential selection by showing no genome-wide relationship between sex differences in expression and selection on eQTLs across 39 human tissues.

Single-cell RNA Sequencing Reveals Methamphetamine Inhibits the Liver Immune Response with Involvement of the Dopamine D1 Receptor

This study uses single-cell RNA sequencing to show that chronic methamphetamine exposure alters liver immune cell composition and function, with involvement of the dopamine D1 receptor.

New isolates refine the ecophysiology of the Roseobacter CHAB-I-5 lineage

The paper isolates two new CHAB-I-5 strains, analyzes their genomes, and proposes a new genus and species, highlighting ecological and physiological differences.

CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality

This study shows CDK12 loss drives prostate cancer development and identifies CDK13 as a therapeutic target through paralog-based synthetic lethality in CDK12-mutant tumors.

Evolutionary trajectory of TRPM2 channel activation by adenosine diphosphate ribose and calcium

The paper traces the evolutionary changes in TRPM2 channel activation mechanisms across species, identifying key stages in the transition from simple to complex ligand binding and calcium gating.

Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer

This study identifies PIKfyve as a targetable vulnerability in pancreatic cancer by showing its role in lipid metabolism and synthetic lethality with KRAS-MAPK inhibitors.

Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer

This paper develops an orally bioavailable PROTAC degrader of mSWI/SNF ATPases for prostate cancer and identifies resistance mechanisms through long-term treatment.

A Real-time Multi-Subject Three Dimensional Pose Tracking System for Analyzing Social Behaviors of Non-human Primates

This paper introduces MarmoPose, a real-time 3D pose tracking system for non-human primates, enabling analysis of social behaviors and closed-loop experiments in marmosets.

Single cell dissection of developmental origins and transcriptional heterogeneity in B-cell acute lymphoblastic leukemia

This study uses scRNA-seq to analyze B-ALL samples, revealing transcriptional heterogeneity and developmental origins, with specific subtypes associated with distinct cell populations and clinical outcomes.

pan-MHC and cross-Species Prediction of T Cell Receptor-Antigen Binding

This paper develops pMTnet-omni, an AI system predicting TCR-pMHC binding across species and MHC classes, achieving high accuracy and showing clinical utility in predicting immune-related adverse events.

Structure of scavenger receptor SCARF1 and its interaction with lipoproteins

This study determines the structure of SCARF1 and identifies its ligand recognition mechanism, revealing key residues and shared binding sites for modified LDLs and bacterial teichoic acids.

Zinc Regulates the Copper Reductase Activity of Yeast Nucleosomes

This study shows yeast nucleosomes have copper reductase activity regulated by zinc, which affects copper bioavailability and cellular growth.

The Effect of Mechanical Stimuli on the Phenotypic Plasticity of Induced Pluripotent Stem Cell-Derived Vascular Smooth Muscle Cells in a 3D Hydrogel

This study examines how mechanical stimuli affect the phenotypic plasticity of hiPSC-derived vascular smooth muscle cells in 3D hydrogels, showing they adapt similarly to primary cells.

CDK19 and CDK8 Mediator kinases drive androgen-independent in vivo growth of castration-resistant prostate cancer

This study identifies CDK8 and CDK19 as drivers of androgen-independent growth in castration-resistant prostate cancer and shows that their inhibition can suppress tumor growth and induce regression.

Circulating metabolites of Borneolum syntheticum (Bingpian) inhibit foam-cell formation in macrophages induced by oxidized low-density lipoprotein

Prolonging lung cancer response to EGFR inhibition by targeting the selective advantage of resistant cells

This study shows that sorafenib can prolong lung cancer response to EGFR inhibitors by targeting resistant cells' selective advantage.

Identification of differentially recognized T cell epitopes in the spectrum of Mtb infection

The paper identifies differentially recognized T cell epitopes in Mtb infection stages using a proteome-wide screen and Fluorospot assay, revealing epitopes specific to active TB and potential vaccine targets.

Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice

This study shows that oral administration of indole-3-acetate reduces liver steatosis and inflammation in mice fed a high-fat diet.

Engineered ketocarotenoid biosynthesis in the polyextremophilic red microalga Cyanidioschyzon merolae 10D

This paper demonstrates the successful engineering of ketocarotenoid biosynthesis in the red microalga C. merolae 10D using heterologous enzymes, enabling simultaneous production of phycocyanin and ketocarotenoids.

The AEGEAN-169 clade of bacterioplankton is synonymous with SAR11 subclade V (HIMB59) and metabolically distinct

This paper demonstrates that SAR11 subclade V is synonymous with the AEGEAN-169 clade and shows they have distinct metabolic capabilities compared to SAR11.

A complex three-dimensional microfluidic model that mimics the early stage events in the human atherosclerotic artery

This paper develops a 3D microfluidic model of early human atherosclerosis with co-cultured cells and flow to study immune cell recruitment and disease mechanisms.

ADO-MEDIATED SYNTHESIS OF TAURINE ALTERS THE CHROMATIN LANDSCAPE OF INGUINAL ADIPOSE TISSUE TO ENHANCE NON-SHIVERING THERMOGENESIS

This study shows taurine biosynthesis via ADO enhances NST in inguinal adipose tissue by remodeling chromatin to increase gene transcription for thermogenesis.

Chemical Imaging Reveals Diverse Functions of Tricarboxylic Acid Metabolites in Root Growth and Development

The paper uses chemical imaging to show that TCA cycle metabolites have distinct roles in root growth and development across species.

Characterizing control of memory CD8 T cell differentiation by BTB-ZF transcription factor Zbtb20

This study identifies Zbtb20's role in regulating transcriptional and epigenetic programs during CD8 T cell differentiation and memory formation.

Ecophysiology and genomics of the brackish water adapted SAR11 subclade IIIa

This study presents the most comprehensive pangenomic analysis of SAR11 subclade IIIa, revealing ecological and metabolic differentiation across its subgroups and bridging marine and freshwater adaptations.

Protein Lactylation and Metabolic Regulation of the Zoonotic Parasite Toxoplasma gondii

This study maps lactylation sites in Toxoplasma gondii and identifies its role in gene regulation and metabolic processes.

Prefusion-Stabilized Lassa Virus Trimer Identifies Neutralizing Nanobodies and Reveals an Apex-Situated Site of Vulnerability

This paper develops a prefusion-stabilized Lassa virus GPC, identifies a neutralizing nanobody, and reveals a cleavage-dependent site of vulnerability at the trimer apex.

Single-cell transcriptomics reveal hyperacute cytokine and immune checkpoint axis in patients with poor neurological outcomes after cardiac arrest

The paper uses single-cell transcriptomics to identify immune cell states and cytokine interactions linked to poor neurological outcomes after cardiac arrest.

Elevated FAM84B promotes cell proliferation via interacting with NPM1 in esophageal squamous cell carcinoma

This study identifies FAM84B amplification as a marker of poor prognosis in ESCC and shows it promotes cell proliferation by interacting with NPM1 to suppress CDKN2A.

Rapid and Durable Protection Against Marburg Virus with a Single-Shot ChAd3-MARV GP Vaccine

A single-shot ChAd3-MARV vaccine provided rapid and durable protection against lethal Marburg virus infection in macaques, with antigen-specific antibodies correlating strongly with immunity.