J. Xu

Function and firing of the Streptomyces coelicolor contractile injection system requires the membrane protein CisA

This study identifies CisA as a membrane protein essential for the function of the Streptomyces coelicolor contractile injection system, showing it mediates recruitment to the membrane and firing.

Impact of Glycan Depletion, Glycan Debranching and Increased Glycan Charge on HIV-1 Neutralization Sensitivity and Immunogenicity

This study evaluates glycoengineered HIV-1 trimers to enhance bNAb recognition, finding that B4GalT1+ST6GalT1 modifications increase antibody titers in infected donors but reduce vaccine-induced neutralizing antibodies.

Metabolomics profiling reveals association of fermented herbal feed additive, growth performance and gut microbiota in piglets

This study shows that fermented Chinese medicine (FCM) improves piglet growth and health by increasing lactic acid and propionic acid levels and altering gut microbiota composition.

An Omni-Mesoscope for multiscale high-throughput quantitative phase imaging of cellular dynamics and high-content molecular characterization

The paper introduces the Omni-Mesoscope, a cost-effective imaging platform that combines quantitative phase microscopy and multiplex fluorescence imaging to study cellular dynamics and molecular characteristics.

Clathrin-associated carriers enable recycling through a kiss-and-run mechanism

The paper identifies a novel endocytic recycling mechanism called CARP, which involves clathrin-associated carriers undergoing partial membrane fusion and release.

An efficient method for visualizing the plaques of Bdellovibrio bacteriovorus

This paper introduces a method using fluorescent prey to visualize Bdellovibrio bacteriovorus plaques faster, reducing incubation time from 3 days to 1.5 days.

A lever hypothesis for Synaptotagmin-1 action in neurotransmitter release

This paper proposes a lever hypothesis for Synaptotagmin-1 action in neurotransmitter release, suggesting it pulls SNARE complexes to facilitate membrane fusion.

Cas12a/3 crRNAs RNP transformation enables transgene-free multiplex genome editing, long deletions, and inversions in citrus chromosome in the T0 generation

Chemoresistance of TP53 mutant AML requires the mevalonate byproduct, GGPP, for regulation of ROS and induction of a mitochondria stress response

This study identifies GGPP, a mevalonate pathway byproduct, as critical for chemoresistance in TP53mut AML through ROS regulation and mitochondria stress response, suggesting statin-based therapies could be effective.

The Dual Roles of the CXCL10-CXCR3 Axis and Its Therapeutic Potential in Osteosarcoma

This study investigates the dual role of the CXCL10-CXCR3 axis in osteosarcoma, showing it promotes tumor growth but also recruits immune cells, suggesting CXCR3 inhibition could target metastasis.

Dynamic Modeling of Antibody Repertoire Reshaping in Response to Viral Infections

This study uses mathematical modeling to show that viral infections reshape the antibody repertoire through the proliferation of high-affinity antibody pools and contraction of low-affinity pools, with self-antigens maintaining antibody persistence.

The 11β-hydroxysteroid dehydrogenase type 1 inhibitor SPI-62 prevents morbidity in a mouse model of Cushing's syndrome

SPI-62, an HSD-1 inhibitor, reduces GC-induced morbidity in a mouse Cushing's syndrome model by improving insulin sensitivity, reducing adiposity, and preventing skeletal myopathy.

Inactivation of PRMT1 inhibits cardiac fibrosis via transcriptional regulation and perturbation of FBL activity in fibroblast-to-myofibroblast transition

This study shows that inhibiting PRMT1 reduces cardiac fibrosis by blocking fibroblast-to-myofibroblast transition through transcriptional regulation and disruption of FBL activity.

Highly sensitive mapping of in vitro type II topoisomerase DNA cleavage sites with SHAN-seq

This study develops SHAN-seq to map type II topoisomerase cleavage sites on DNA with high sensitivity, revealing hundreds of sites and enzyme-specific variations.

LncCE: Landscape of Cellular-Elevated LncRNAs in Single Cells Across Normal and Cancer Tissues

LncCE identifies and characterizes cellular-elevated lncRNAs across normal and cancer tissues using single-cell RNA sequencing data, providing expression patterns and clinical associations.

eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer

This paper identifies eIF4A as a key regulator of ER translation in breast cancer and shows that inhibiting eIF4A, either alone or with fulvestrant, suppresses ER expression and tumor growth in advanced ER+ breast cancer.

Mitochondrial Oxidative Phosphorylation Capacity in Skeletal Muscle Measured by Ultrafast Z-Spectroscopy (UFZ) MRI at 3T

This study evaluates ultrafast Z-spectroscopy MRI with pH correction for measuring mitochondrial oxidative phosphorylation in human skeletal muscle.

Archaeal type six secretion system mediates contact-dependent antagonism

The paper identifies a contact-dependent antagonism mechanism in archaea mediated by a CIS similar to bacterial T6SSs, revealing its role in shaping microbial communities.

All-trans retinoic acid induces durable tumor immunity in IDH-mutant gliomas by rescuing transcriptional repression of the CRBP1-retinoic acid axis

This study shows that all-trans retinoic acid (ATRA) improves immune response in IDH-mutant gliomas by restoring the RA pathway, leading to tumor regression in mouse models and a clinical trial for human patients.

Plant Development Drives Dynamic Shifts in the Root Compartment Microbiomes of Wild and Domesticated Finger Millet Cultivars

This study examines how plant developmental stage and domestication influence microbial communities in root compartments of finger millet, showing significant shifts in bacterial and fungal phyla.

Structure and function of an intermediate GPCR-G protein complex

The paper resolves the structure of an intermediate GPCR-G protein complex and shows it initiates nucleotide exchange without progressing to the fully activated state, providing insights into GPCR signaling complexity.

The Role of Morphological Adaptability in Vibrio cholerae's Motility and Pathogenicity

This study examines how morphological changes in Vibrio cholerae affect its motility and pathogenicity in different viscosity environments.

FilamentID reveals the composition and function of metabolic enzyme polymers during gametogenesis

The paper introduces FilamentID, a workflow to identify filament composition in cells, finding Ald4ALDH2 and Acs1ACSS2 form filaments in mitochondria and nucleus during meiosis, aiding cell recovery from stress.

Loss of an extensive ciliary connectome induces proteostasis and cell fate switching in a severe motile ciliopathy

The paper identifies cellular defects beyond motility loss in ciliopathies caused by CCDC39/CCDC40 variants, showing proteostasis disruption and cell fate switching.

Mapping the Cellular Biogeography of Human Bone Marrow Niches Using Single-Cell Transcriptomics and Proteomic Imaging

This study maps human bone marrow niches using single-cell transcriptomics and proteomic imaging, identifying distinct cellular environments and their roles in hematopoiesis and AML.

Development of alcoholic liver disease model for drug evaluation from human induced pluripotent stem cell derived liver organoids

This study develops a human induced pluripotent stem cell-derived liver organoid model of alcoholic liver disease to evaluate drug treatments and replicate key pathological features.

A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade glioma

This study creates a longitudinal multiomic atlas of pediatric high-grade glioma, revealing distinct tumor cell states and therapeutic targets not seen in adult glioblastoma.

A resource to enable chemical biology and drug discovery of WDR Proteins

The paper develops a resource for discovering ligands for WDR proteins using experimental and computational methods, leading to the identification of drug-like ligands for 9 out of 20 targets.

Molecular basis of inhibition of the amino acid transporter B0AT1 (SLC6A19)

This paper identifies high-affinity inhibitors of B0AT1 and elucidates their mechanism of action through cryo-EM structures.

Jianpi Jiedu Recipe inhibits proliferation through reactive oxygen species-induced incomplete autophagy and reduces PD-L1 expression in colon cancer