Inhibition of extracellular vesicle-encapsulated miRNA produced by estrogen-mediated upregulation of cellular processing suppresses target organ inflammation in a humanized model of systemic lupus erythematosus
N. A. Young, E. Schwarz, R. A. Mesa, K. Jablonski, L.-C. Wu, E. D. O. Roberson, W. Jarjour
This study shows that estrogen increases miRNA production in extracellular vesicles from SLE patients, and inhibiting these miRNAs reduces inflammation in a humanized mouse model.
bioRxiv · Nov 3, 2022 · PreprintImmunology