ImmunologybioRxivPreprint
Inhibition of extracellular vesicle-encapsulated miRNA produced by estrogen-mediated upregulation of cellular processing suppresses target organ inflammation in a humanized model of systemic lupus erythematosus
N. A. Young, E. Schwarz, R. A. Mesa…·W. Jarjour
This study shows that estrogen increases miRNA production in extracellular vesicles from SLE patients, and inhibiting these miRNAs reduces inflammation in a humanized mouse model.
DOI 10.1101/2022.11.03.514940