J. Sharma

Most azole antifungal resistance mutations in the drug target provide cross-resistance and carry no intrinsic fitness cost

The paper evaluates 4,000 Erg11 variants to determine azole resistance and fitness costs, finding 33% resistance, 88% cross-resistance, and minimal fitness cost.

How a disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization

The paper investigates how a disordered linker in the Polyhomeotic protein influences phase separation and oligomerization in Drosophila and human cells through in vitro reconstitution and molecular dynamics simulations.

TFEB degradation is regulated by an IKK/β-TrCP2 phosphorylation-ubiquitination cascade

This study identifies an IKK/β-TrCP2 phosphorylation-ubiquitination cascade that regulates TFEB stability, independent of other regulators.

The soluble guanylyl cyclase pathway is inhibited to evade androgen deprivation-induced senescence and enable progression to castration resistance

This study identifies the soluble guanylyl cyclase (sGC) pathway as a target for castration-resistant prostate cancer (CRPC) treatment, showing that riociguat inhibits CRPC growth and enhances radiation response.

Salmonella Typhimurium effector SseI regulates host peroxisomal dynamics to acquire lysosomal cholesterol for better intracellular growth

The paper shows Salmonella effector SseI recruits peroxisomes to SCVs, activates ARF-1, and facilitates cholesterol transport for bacterial growth.

The prophylactic value of TNF-alpha inhibitors against retinal cell apoptosis and optic nerve axon loss after corneal surgery or trauma

This study evaluates the toxicity and efficacy of TNF-alpha inhibitors adalimumab and infliximab in preventing retinal cell apoptosis and optic nerve axon loss in rabbits after corneal injury.

Development and applications of a CRISPR activation system for facile genetic overexpression in Candida albicans

This paper develops a CRISPR activation system for genetic overexpression in Candida albicans and demonstrates its ability to drive high-level gene expression and identify novel phenotypes.

Aromatase Inhibitor Induced Musculoskeletal Inflammation is Observed Independent of Oophorectomy in a Novel Mouse Model

This study develops a novel mouse model showing aromatase inhibitor-induced musculoskeletal inflammation occurs independently of oophorectomy and estrogen deficiency.

Hemodynamic molecular imaging of tumor-associated enzyme activity in the living brain.

This paper develops a molecular sensor to noninvasively map FAP enzyme activity in the brain, demonstrating its utility in rats and nonhuman primates for detecting tumor-associated biomarkers.

Decoding the role of CBLB for innate immune responses regulating systemic dissemination during Non-Tuberculous Mycobacteria infection

This study investigates the role of CBLB in innate immune responses during NTM infection, finding it essential for preventing dissemination under T-cell deficiency.

Close range vocal interaction in the common marmoset (Callithrix Jacchus)

This study examines trill calls in common marmosets, showing that social context affects call rates and spectral properties, and that trills are primarily exchanged with partners.

A CLN6-CLN8 complex recruits lysosomal enzymes at the ER for Golgi transfer

The paper identifies CLN6 and the EGRESS complex as essential for lysosomal enzyme trafficking from the ER to the Golgi, revealing their role in Batten disease pathogenesis.