K. Karbstein

Unstructured Domains in Assembly Factors Promote the Hierarchy of Ribosome Maturation via Their Structural Plasticity.

The paper investigates how the non-globular structure of the assembly factor Ltv1 uses structural plasticity to coordinate 40S ribosome subunit maturation and reveals its role in quality control and human disease.

The modifying enzyme Tsr3 establishes the hierarchy of Rio kinase activity in 40S ribosome assembly

This study shows that Tsr3 establishes a hierarchy between Rio2 and Rio1 kinases during 40S ribosome assembly by preventing Rio2 rebinding and enabling Rio1 recruitment.

Blocking a dead-end assembly pathway creates a point of regulation for the DEAD-box ATPase Has1 and prevents platform misassembly

The paper shows that Rrp36 regulates ribosome assembly by preventing a dead-end pathway, allowing Has1 to correct misfolding and ensure proper platform assembly.

Unraveling phylogenetic relationships, reticulate evolution, and genome composition of polyploid plant complexes by RAD-Seq and Hyb-Seq

This study uses RAD-Seq and Hyb-Seq data to analyze the phylogenetic relationships and genome evolution of the Ranunculus auricomus polyploid complex, revealing allopolyploid origins and post-origin evolutionary processes.

An open interface in the pre-80S ribosome coordinated by ribosome assembly factors Tsr1 and Dim1 enables temporal regulation of Fap7

The paper determines the structure of an 80S-like ribosome assembly intermediate, revealing how Tsr1 and Dim1 coordinate to regulate Fap7 and enable quality control during ribosome maturation.

Assembly factors chaperone rRNA folding by isolating helical junctions that are prone to misfolding

The paper identifies three-way junctions as prone to misfolding during ribosome assembly and shows how assembly factors and snoRNAs chaperone their folding to prevent kinetic trapping.

Phylogenomics supported by geometric morphometrics reveals delimitation of sexual species within the polyploid apomictic Ranunculus auricomus complex (Ranunculaceae)

The paper delimits sexual species within the polyploid apomictic Ranunculus auricomus complex using phylogenomic and geometric morphometric methods, identifying five main genetic and morphological lineages.

Phylogenomics unravels speciation patterns in temperate-montane plant species: a case study on the recently radiating Ranunculus auricomus species complex

This study uses phylogenomic data to analyze speciation patterns in the Ranunculus auricomus complex, finding that vicariance processes drove speciation during the Mid-Pleistocene Transition.