X. Liu

EigenBrain maps cortical molecular architecture from functional, geometric, and structural eigenmodes

The paper shows functional MRI eigenmodes can approximate specific receptor and transporter distributions in the cortex, while structural and geometric eigenmodes cannot, and applies this to detect molecular differences in autism and schizophrenia.

THIK-1 channel mediates microglial glucose sensing and modulates AgRP neurons

This study identifies THIK-1 channel as a glucose sensor in microglia that modulates AgRP neuron activity and feeding behavior in diet-induced obesity.

An Unbiased Proteomic Platform for ATE1-based Arginylation Profiling

The paper introduces an unbiased proteomic platform for ATE1-based arginylation profiling, identifying 235 unique arginylation sites in human proteomes.

Structure of the minor spliceosomal U11 snRNP

The paper presents a cryo-EM structure of the U11 snRNP complex, revealing its unique architecture and interactions critical for U12-dependent intron recognition.

Immunoregulatory macrophages modify local pulmonary immunity and ameliorate hypoxic-pulmonary hypertension

The paper shows that administering anti-inflammatory macrophages reduces inflammation and pulmonary hypertension in mice exposed to hypoxia.

The evolution of autonomy from two cooperative specialists in fluctuating environments

This study shows that autonomous genotypes can evolve from cooperative microbial specialists in fluctuating environments through horizontal gene transfer.

The Impact of Preprints on the Citations of Journal Articles Related to COVID-19

This study compares citation counts of COVID-19 papers distributed as preprints versus those directly submitted to journals, finding preprints received significantly more citations in 70.11% of journals.

Equip Fusobacterium nucleatum genetic tool kits with compatible shuttle vectors and engineered intermediatory E. coli strains for enhanced transformation efficiency

This paper develops genetic tools for Fusobacterium nucleatum by engineering E. coli intermediates and shuttle vectors, achieving 5000 transformants per microgram plasmid.

Bioadhesive Hydrogel-Coupled and Miniaturized Ultrasound Transducer System for Long-Term, Wearable Neuromodulation

This paper develops a wearable ultrasound device with bioadhesive hydrogel for long-term neuromodulation, demonstrating its effectiveness in suppressing somatosensory responses over 28 days.

Single-Cell and Spatial Transcriptomic Analyses Deciphering the Three-Layer Architecture of Human Tuberculosis Granulomas

This study uses single-cell and spatial transcriptomics to analyze human tuberculosis granulomas, revealing a three-layer structure and identifying potential therapeutic targets.

Clathrin-associated carriers enable recycling through a kiss-and-run mechanism

The paper identifies a novel endocytic recycling mechanism called CARP, which involves clathrin-associated carriers undergoing partial membrane fusion and release.

Optimization of gene knockout approaches and practical solutions to sgRNA selection challenges in hPSCs with inducible Cas9 system

This study optimizes gene knockout in hPSCs using an inducible Cas9 system and identifies effective sgRNAs by comparing experimental results with cleavage efficiency algorithms.

Make-or-break prime editing for bacterial genome engineering

This paper develops mbPE, a prime editing system for Streptococcus pneumoniae that enables precise genome editing without donor DNA, achieving high selection efficiencies for point mutations, deletions, and insertions.

Decoding the anti-aging effect of retinol in reshaping the human skin microbiome niches

This study investigates how retinol affects the human skin microbiome and its role in retinol's anti-aging effects using phenomics, metagenomics, and metabolomics.

Multiomics mapping and characterization of cellular senescence in aging human skeletal muscle uncovers a novel senotherapeutic for sarcopenia

This study uses single-nucleus multiomics to characterize senescence in human skeletal muscle, identifies SASP factors, and proposes Maraviroc as a senotherapeutic for sarcopenia.

Os-circANK negatively regulates resistance to bacterial blight in rice via Osa-miR398b/OsCSD1/OsCSD2 pathways

The paper identifies Os-circANK as a circRNA that suppresses rice resistance to bacterial blight by sponging Osa-miR398b and modulating OsCSD1/OsCSD2 expression.

Calorie Restriction Induces Degeneration of Neurons with Mitochondrial DNA Depletion by Altering ER-Mitochondria Calcium Transfer

This study shows that calorie restriction exacerbates neuronal degeneration in mtDNA-depleted neurons by increasing ER-mitochondria calcium transfer, suggesting CR may not be beneficial for mitochondrial epilepsy.

Mealtime alters daily rhythm in nuclear O-GlcNAc proteome to regulate hepatic gene expression

This study shows that mealtime affects the daily rhythm of nuclear O-GlcNAc proteome in mice, which regulates hepatic gene expression through interactions with phosphorylation.

Multi-dimensionality of tree communities structure host-parasitoid networks and their phylogenetic composition

The paper examines how tree diversity and canopy cover affect host-parasitoid community composition and interaction networks in a subtropical tree biodiversity experiment.

Cathartocytosis: Jettisoning of Unwanted Material during Cellular Reprogramming

The paper describes a novel lysosome-independent process called cathartocytosis, where cells eject unwanted material during reprogramming, distinct from autophagy.

Transcriptional reprogramming deploys a compartmentalized "timebomb" in Catharanthus roseus to fend off chewing herbivores

This study identifies a transcription factor that coordinates the production of insecticidal alkaloids in response to herbivory and cold stress in Catharanthus roseus.

Brain-derived exosomal hemoglobin transfer contributes to neuronal mitochondrial homeostasis under hypoxia

This study identifies exosomal hemoglobin transfer from non-neuronal cells to neurons under hypoxia as a mechanism to maintain mitochondrial homeostasis and protect against neurological injury.

Bola-amphiphilic dendrimer empowers imatinib to target metastatic ovarian cancer stem cells via beta-catenin-HRP2 signaling axis

This study develops a nanoformulation Bola/IM to target metastatic ovarian cancer stem cells via the beta-catenin-HRP2 signaling axis, showing improved efficacy and synergy with cisplatin.

Deciphering the Preeclampsia-Specific Immune Microenvironment: The Role of Pro-inflammatory Macrophages

This study identifies pro-inflammatory macrophages as key regulators of the PE-specific immune microenvironment, linking them to Th17 and CD8+ T cell activation and gMDSC suppression in placental tissues.

Structures of PSI-FCPI from Thalassiosira pseudonana in high light provide convergent evolution and light-adaptive strategies in diatom FCPIs

The paper reports cryo-EM structures of PSI-FCPI complexes from Thalassiosira pseudonana under high light, revealing light-adaptive strategies and convergent evolution in diatom FCPIs.

On the discovered Cancer Driving Nucleotides (CDNs)-Distributions across genes, cancer types and patients

This study identifies Cancer Driving Nucleotides (CDNs) across cancer types and patients, finding that most remain unidentified and highlights the need for larger sample sizes to improve detection.

The theory of massively repeated evolution and full identifications of Cancer Driving Nucleotides (CDNs)

This study develops a theory to identify Cancer Driving Nucleotides (CDNs) by analyzing mutation recurrence across large cancer datasets, finding that mutations recurring at least three times are likely CDNs.

The Impact of Preprints on COVID-19 Research Dissemination: A Quantitative Analysis of Journal Publications

The paper quantifies the role of preprints in COVID-19 research dissemination, showing their increased acceptance in high-impact journals.

Stearoyl coenzyme A desaturase 1 (SCD1) regulates foot-and-mouth disease virus replication by modulating host cell lipid metabolism and 2C-mediated replication complex formation

This study shows SCD1 regulates FMDV replication by modulating lipid metabolism and 2C-mediated replication complex formation, suggesting it as a potential drug target for positive-sense RNA viruses.

Mechanical forces instruct division plane orientation of cambium stem cells during radial growth in Arabidopsis thaliana

The paper investigates how mechanical forces guide cambium stem cell division plane orientation in Arabidopsis thaliana during radial growth using simulations and anatomical analyses.