S. Choi

Classification of Variants of Reduced Penetrance in High Penetrance Cancer Susceptibility Genes: Framework for Genetics Clinicians and Clinical Scientists by CanVIG-UK (Cancer Variant Interpretation Group-UK)

The paper develops a framework for classifying variants of reduced penetrance in cancer susceptibility genes to improve variant interpretation consistency.

Ongoing genome doubling promotes evolvability and immune dysregulation in ovarian cancer

This study shows that ongoing whole-genome doubling in ovarian cancer promotes cell diversity and immune dysregulation through chromosomal instability and quiescent states.

A HigB-like toxin promotes non-replicating Salmonella inside macrophages by inhibiting ribonuclease III

This study identifies a HigB-like toxin in Salmonella that inhibits RNase III, leading to non-replicating bacteria within macrophages.

The cochlear hook region detects harmonics beyond the canonical hearing range

The paper shows that the cochlear hook region in guinea pigs detects ultrasound harmonics beyond the typical hearing range through resonance and nonlinear amplification.

Assessing Long-Term Stored Tissues for Multi-Omics Data Quality and Proteogenomics Suitability

This study evaluates the quality and suitability of long-term stored tissues for multi-omics analyses, showing that while transcriptomic data show some changes, core gene expression and proteomic measurements remain reliable.

Mechanisms of genomic instability dictate cytosolic DNA composition and dendritic cell mediated anti-tumor immunity

The paper shows that genomic instability in MSI CRCs generates cytosolic DNA that enhances STING activation and anti-tumor immunity via dendritic cells, suggesting improved DNA-based therapies for CIN CRCs.

Collagen mineralization decreases NK cell-mediated cytotoxicity of breast cancer cells via increased glycocalyx thickness

This study shows that collagen mineralization increases NK cell resistance in breast cancer by thickening the tumor cell glycocalyx through enhanced sialylation.

IN SILICO DESIGN AND BINDING MECHANISM OF E3 LIGASE UBR1 RECRUITERS

The paper designs and analyzes E3 ligase UBR1 recruiters using computational methods to identify promising PROTAC components.

Candidatus Nitrosocosmicus members are the dominant archaea associated with pepper (Capsicum annuum L.) and ginseng (Panax ginseng C.A. Mey.) plants rhizospheres

The paper identifies Candidatus Nitrosocosmicus as dominant ammonia-oxidizing archaea in rhizospheres of pepper and ginseng, showing their MnKat gene abundance and catalytic activity.

Enhanced functionalities of immune cells separated by microfludic lattice: assessment based on holotomography

This study compares microfluidic and centrifugation methods for isolating white blood cells, finding microfluidic separation better preserves cell functionality.

Sulfasalazine promotes myogenic differentiation via increasing of fast myosin heavy chain isoforms

This study shows sulfasalazine promotes myogenic differentiation by increasing fast myosin heavy chain isoforms through a metabolic shift to glycolysis in C2C12 myoblasts and improves muscle function in aged and injured mice.

Highly effective gene inactivation in tetraploid Xenopus laevis with low-temperature-active engineered Cas12a

This study evaluates engineered Cas12a variants for gene inactivation in Xenopus laevis, finding that Cas12a-Ultra achieves high efficiency at low temperatures.

Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis

This study identifies CtBP2 as a mediator of Bcl-xL nuclear translocation, which promotes metastasis by enhancing H3K4me3 and TGFβ transcription.

Xylazine effects on opioid-induced brain hypoxia

This study investigates how xylazine affects brain hypoxia when combined with opioids, finding that it worsens brain hypoxia and reduces compensatory mechanisms.

RNA folding studies inside peptide-rich droplets reveal roles of modified nucleosides at the origin of life

The paper shows that RNA folds into native structures in protocell models, and this is enhanced by covalent modifications, suggesting a role in early life processes.

Isolation may select for earlier and higher peak viral load but shorter duration in SARS-CoV-2 evolution

This study shows isolation measures during the pandemic selected for SARS-CoV-2 variants with earlier and higher peak viral loads but shorter infection duration.

Structural insights into ion conduction by novel cation channel, TMEM87A, in Golgi apparatus

This paper presents a high-resolution cryo-EM structure of TMEM87A, revealing its unique architecture and mechanisms of ion conduction and gating in the Golgi apparatus.

Sniper2L, a high-fidelity Cas9 variant with high activity

This paper develops Sniper2L, a high-fidelity Cas9 variant with improved specificity and retained high on-target activity, and introduces a deep-learning model to predict its activity.

Intrinsically disordered proteins SAID1/2 condensate on SERRATE/ARS2 for dual inhibition of miRNA biogenesis in Arabidopsis

This study identifies SAID1/2 as negative regulators of miRNA biogenesis in Arabidopsis by inhibiting the microprocessor complex through phase condensation and SE degradation.

Lack of specificity in Geobacter periplasmic electron transfer

This study shows that multiple triheme periplasmic cytochromes in Geobacter sulfurreducens are promiscuous in electron transfer, supporting metal reduction but not electrode respiration.

Dynamic allosteric networks drive adenosine A1 receptor activation and G-protein coupling

This study identifies dynamic allosteric networks in the adenosine A1 receptor that drive activation and G-protein coupling through molecular dynamics simulations and network analysis.

Microstructural and crystallographic evolution of palaeognath (Aves) eggshells

This study analyzes the microstructure and crystallography of palaeognath eggshells across clades to determine evolutionary relationships and ancestral states.

Biofunctional matrix models reveal mineral-dependent mechanoregulation of bone metastatic breast cancer

The paper shows that mineralization in bone matrix models inhibits tumor cell proliferation and induces a stem-like phenotype, contradicting the assumption that rigidity promotes metastasis.

Aging reduces the number and function of L-type calcium channels in the membrane of cardiac pacemaker cells

This study shows that aging reduces L-type calcium channel density, clustering, and open probability in cardiac pacemaker cells, leading to a slowdown in pacemaker rate, which can be reversed pharmacologically.

P176S polymorphism in Maspin rewires electrostatic interaction that alters Maspin functionality

This study shows that the P176S polymorphism in Maspin alters electrostatic interactions, affecting its function and binding properties in cancer.

Ptr1 and ZAR1 immune receptors confer overlapping and distinct bacterial pathogen effector specificities

The paper identifies effector recognition specificities of NbPtr1 and NbZAR1 in N. benthamiana and shows their distinct and overlapping roles in detecting bacterial effectors.

Experimental and mathematical models of intracellular calcium dynamics for evaluating combined anticancer effects of Afatinib and RP4010 in esophageal cancer

Hyperactivation of YAP/TAZ drives alterations in mesangial cells through stabilization of N-MYC in diabetic nephropathy

This study shows that YAP/TAZ hyperactivation in mesangial cells drives diabetic nephropathy by stabilizing N-Myc, leading to cellular impairments and disease progression.

Cooperative binding of TCR and CD4 to pMHC enhances TCR sensitivity

The paper shows CD4 enhances TCR sensitivity by forming trimolecular bonds with pMHC, which are stabilized by force and proximity.

A p53-Phosphoinositide Signalosome Regulates Nuclear Akt Activation

The paper shows p53 forms a nuclear PI3K-Akt pathway that activates Akt independently of the canonical membrane pathway, with implications for cancer therapy.