Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors
J. B. Foster, C. Griffin, J. L. Rokita, A. Stern, C. Brimley, K. Rathi, M. V. Lane, S. N. Buongervino, T. Smith, P. J. Madsen, D. Martinez, R. Wechsler-Reya, K. Kariko, P. B. Storm, D. M. Barrett, , K. R. Bosse
This study develops mRNA chimeric antigen receptor T cells targeting GPC2 on pediatric brain tumors, showing significant tumor regression and prolonged survival without toxicity.
bioRxiv · Jul 6, 2021Cancer Biology