D. Martinez

A proteogenomic surfaceome study identifies DLK1 as an immunotherapeutic target in neuroblastoma

This study identifies DLK1 as a potential immunotherapeutic target in neuroblastoma through integrative proteomic, transcriptomic, and epigenomic analysis.

Vaccine-mediated protection against merbecovirus and sarbecovirus challenge in mice

This study develops a trivalent RBD nanoparticle vaccine that protects mice against both merbecovirus and sarbecovirus challenges, including SARS-CoV, MERS-CoV, and SARS-CoV-2.

Hep3D: A 3D single-cell digital atlas of the liver to study spatio-temporal tissue architecture

The paper develops Hep3D, a 3D single-cell atlas of the mouse liver, revealing spatiotemporal patterns of cellular structures and the structural role of Kupffer cells in liver homeostasis.

Targeting Spike Glycans to Inhibit SARS-CoV2 Viral Entry

This study shows that BOA, a lectin, binds to SARS-CoV-2 Spike glycans and inhibits viral entry at nanomolar concentrations, effective against variants of concern.

Quantitative analyses of T cell motion in tissue reveals factors driving T cell search in tissues

This study quantifies T cell motion in different tissues and finds that tissue environment affects motility patterns, impacting T cell search efficiency.

A Multitrait Locus Regulates Sarbecovirus Pathogenesis

The paper identifies a multitrait locus on mouse Chromosome 9 that regulates SARS-CoV, SARS-CoV-2, and bat sarbecovirus disease severity, with candidate genes CCR9 and CXCR6.

Vertical HIV-1 transmission in the setting of maternal broad and potent antibody responses

This study examines maternal broadly neutralizing antibody (bnAb) specificities in HIV-transmitting and non-transmitting mothers to determine if certain bnAb specificities drive infant transmitted/founder virus selection.

The Role of Mentoring in Promoting Diversity, Equity, and Inclusion in STEM Education and Research

The paper discusses the importance of mentoring in STEM for underrepresented minorities and presents workshop feedback showing student satisfaction despite low initial expectations.

An effective workshop on How to be an Effective Mentor for Underrepresented STEM Trainees

This workshop provides a framework for effective mentorship of underrepresented STEM trainees to address systemic issues in academic pipelines.

Using a Champion-Oriented Mindset to Overcome the Challenges of Graduate School

The paper describes a workshop aimed at preparing minority students for graduate school by fostering a champion-oriented mindset, showing it was well-received and perceived as helpful.

The Importance of Mentors and How to Handle More Than One Mentor

This paper describes a workshop aimed at helping students, especially underrepresented groups, develop effective mentorship skills and relationships in STEM fields.

Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors

This study develops mRNA chimeric antigen receptor T cells targeting GPC2 on pediatric brain tumors, showing significant tumor regression and prolonged survival without toxicity.

Protective efficacy of rhesus adenovirus COVID-19 vaccines against mouse-adapted SARS-CoV-2

This study evaluates the protective efficacy of rhesus adenovirus serotype 52 vaccines against a mouse-adapted SARS-CoV-2 strain, showing robust antibody responses and protection against viral replication and disease.

A broadly neutralizing antibody protects against SARS-CoV, pre-emergent bat CoVs, and SARS-CoV-2 variants in mice

A broadly neutralizing antibody protects against multiple SARS-CoV and SARS-CoV-2 variants in mice by targeting a conserved epitope in the receptor-binding domain.

Prevention and therapy of SARS-CoV-2 and the B.1.351 variant in mice

This study evaluates combination therapies of remdesivir and monoclonal antibodies for SARS-CoV-2 and its B.1.351 variant in mice, showing improved outcomes with the antibody combination.

Different evolutionary pathways of HIV-1 between fetus and mother perinatal transmission pairs indicate unique immune selection pressure in fetuses

This study analyzes HIV-1 env gene evolution in 12 perinatal transmission pairs, finding that most infections occur within two months of birth and fetal viruses show unique selection pressures.

Consequences of the divergence of Methionine AdenosylTransferase

This study investigates the structural and functional consequences of sequence divergence in archaeal Methionine AdenosylTransferase (MAT) compared to bacterial and eukaryotic MATs.

Epigenetic regulator BMI1 promotes fusion-positive rhabdomyosarcoma proliferation and constitutes a novel therapeutic target

This study shows BMI1 promotes FP-RMS proliferation and its inhibition reduces tumor growth and activates the Hippo pathway.

Flotillin mediated membrane fluidity controls peptidoglycan synthesis and MreB movement.

This study shows that bacterial flotillins regulate membrane fluidity, which affects MreB movement and peptidoglycan synthesis.

Single-cell transcriptomic profile reveals macrophage heterogeneity in medulloblastoma and their treatment-dependent recruitment

The paper uses single-cell and bulk RNA sequencing to study macrophage heterogeneity in medulloblastoma and shows differential recruitment with targeted vs. radiation therapy.

Avidity-driven polarity establishment via multivalent lipid-GTPase module interactions

The paper identifies multivalent anionic lipid interactions as critical for establishing cellular polarity through the Cdc42 GTPase module in budding yeast.