DIETARY MONOTERPENOIDS AS A NEW CLASS OF ALLOSTERIC HUMAN ARYL HYDROCARBON RECEPTOR ANTAGONISTS
K. Poulikova, I. Zuvalova, B. Vyhlidalova, K. Krasulova, E. Jiskrova, R. Vrzal, S. Kortagere, M. Kopecna, D. Kopecny, M. Sebela, K. M. Rolfes, T. Haarmann-Stemmann, S. Mani, Z. Dvorak
The paper identifies carvones as non-competitive allosteric antagonists of the AhR, inhibiting target gene induction in a ligand-selective and cell type-specific manner.
bioRxiv · Nov 30, 2020 · PreprintPharmacology & Toxicology