Author

Z. Dvorak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:metagenomics· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

S. Mani· 3 shared B. Vyhlidalova· 2 shared H. Li· 2 shared K. Poulikova· 2 shared S. Kortagere· 2 shared A. Beck· 1 shared A. Chandran· 1 shared A. Matson· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

S. Mani

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Author profile →

3 papers

Recent·Most cited

In Vitro Safety Signals for Potential Clinical Development of the Anti-Inflammatory Pregnane X Receptor Agonist FKK6

Z. Dvorak, B. Vyhlidalov, P. Pecinkov, H. Li, P. Anzenbacher, a. spicakova, e. anzenbacherova, V. Chow, J. LIU, H. Krause, D. J. Wilson, T. Beres, P. Tarkowski, D. Chen, S. Mani

This paper performs in vitro pharmacological profiling of FKK6, showing high PXR selectivity, intestinal permeability, and rapid metabolism, supporting its potential preclinical development.

bioRxiv · Oct 21, 2023Biochemistry

DIETARY MONOTERPENOIDS AS A NEW CLASS OF ALLOSTERIC HUMAN ARYL HYDROCARBON RECEPTOR ANTAGONISTS

K. Poulikova, I. Zuvalova, B. Vyhlidalova, K. Krasulova, E. Jiskrova, R. Vrzal, S. Kortagere, M. Kopecna, D. Kopecny, M. Sebela, K. M. Rolfes, T. Haarmann-Stemmann, S. Mani, Z. Dvorak

The paper identifies carvones as non-competitive allosteric antagonists of the AhR, inhibiting target gene induction in a ligand-selective and cell type-specific manner.

bioRxiv · Nov 30, 2020 · PreprintPharmacology & Toxicology

Targeting the Pregnane X Receptor Using Microbial Metabolite Mimicry

Z. Dvorak, F. Felix Kopp, C. M. Costello, J. S. Kemp, H. Li, A. Vrzalova, M. Stepankova, I. Iveta Bartonkov, K. Poulikova, B. Vyhlidalova, L. U. Nordstroem, C. Karunaratne, H. Ranhotra, K. S. Mun, A. P. Naren, , R. B. Sartor

This paper develops FKK6, a non-cytotoxic PXR agonist derived from microbial metabolite mimicry, which reduces inflammation and validates the strategy for drug discovery.

bioRxiv · Jan 3, 2020Biochemistry