Loss of Tip60-dependent H2A.Z acetylation reprogramscardiomyocyte identity toward a regenerative state.
X. Wang, K. Kulik, T. C. Wan, Z. Qu, J. W. Lough, J. A. Auchampach
This study shows that Tip60-dependent H2A.Z acetylation maintains cardiomyocyte differentiation, and its loss reprograms CMs toward a regenerative state by inducing dedifferentiation and metabolic shifts.
bioRxiv · Jan 11, 2024 · PreprintCell Biology