Author

K. L. Knight

The University of Texas Southwestern Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Irvin T. GarzaiD· 2 shared Rachel M. BaileyiD· 2 shared Sydni K. Holmes· 2 shared Brina SnyderiD· 1 shared Katherine M. Pearce· 1 shared Lauren E. Bailey· 1 shared Meghan M. ElleriD· 1 shared MinJae LeeiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersNeuroscience

Irvin T. GarzaORCID

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2 papers

Recent·Most cited

Preclinical Development of a Vectorized Artificial miRNA Gene Therapy for Tauopathies

Irvin T. Garza, Brina Snyder, Sydni K. Holmes, Katherine M. Pearce, K. L. Knight, Rachel M. Bailey

This paper develops a gene therapy using artificial miRNA delivered via adeno-associated virus to reduce tau in a mouse model of tauopathy, showing efficacy even at late disease stages.

bioRxiv · Oct 12, 2025 · PreprintNeuroscience

AAV-mediated gene therapy for SLC13A5 citrate transporter disorder rescues epileptic and metabolic phenotypes

Lauren E. Bailey, Morgan K. Schackmuth, Raegan M. Adams, Irvin T. Garza, K. L. Knight, Sydni K. Holmes, Meghan M. Eller, MinJae Lee, Rachel M. Bailey

This study shows that AAV-mediated gene therapy in SLC13A5-deficient mice reduces extracellular citrate, normalizes electrophysiologic and sleep issues, and improves seizure resistance.

bioRxiv · Jul 3, 2025 · PreprintNeuroscience