Rational engineering of an elevator-type metal transporter ZIP8 reveals a conditional selectivity filter critically involved in determining substrate specificity
Y. Jiang, Z. Li, D. Sui, G. Sharma, T. Wang, K. MacRenaris, H. Takahashi, K. Merz, J. Hu
This study rationally engineers ZIP8 to alter its substrate specificity, identifying a conditional selectivity filter that determines substrate preference based on transporter conformation.
bioRxiv · Jun 19, 2023Biochemistry