Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment
K. E. Pauken, O. Shahid, K. A. Lagattuta, K. M. Mahuron, J. M. Luber, M. M. Lowe, L. Huang, C. Delaney, J. M. Long, M. E. Fung, K. Newcomer, K. K. Tsai, M. Chow, S. Guinn, J. R. Kuchroo, , M. Singer
The paper identifies circulating anti-tumor CD8 T cells using single-cell RNA sequencing and TCR sequencing, and develops marker panels for their detection in mice and melanoma patients.
bioRxiv · Sep 30, 2020Immunology