Author

D. Depledge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

J. Breuer· 2 shared A. Greninger· 1 shared A. Viejo-Borbolla· 1 shared B. Ritter· 1 shared C. De· 1 shared C. Hartline· 1 shared C. Juergens· 1 shared C. K. Chu· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersMicrobiology

J. Breuer

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Author profile →

4 papers

Recent·Most cited

Viral modulation of type II interferon increases T cell adhesion and virus spread

C. Juergens, G. Ssebyatika, S. Beyer, N. Plueckebaum, K. Kropp, V. Gonzalez-Motos, B. Ritter, H. Boening, E. Nikolouli, P. R. Kinchington, N. Lachmann, D. Depledge, T. Krey, A. Viejo-Borbolla

This study shows that VZV glycoprotein C modulates IFN-γ activity, increasing ICAM1 expression and T cell adhesion, which enhances virus spread from epithelial cells to lymphocytes.

bioRxiv · May 26, 2023 · PreprintMicrobiology

β-L-1- uracil (L-BHDU) effectiveness against varicella-zoster virus and herpes simplex virus type 1 depends on thymidine kinase activity

C. De, D. Liu, D. Depledge, J. Breuer, U. S. Singh, C. Hartline, M. Prichard, C. K. Chu, J. F. Moffat

This study shows L-BHDU's effectiveness against VZV and HSV-1 relies on thymidine kinase activity, as resistant strains have mutations in TK that impair drug phosphorylation.

bioRxiv · Feb 13, 2020 · PreprintMicrobiology

Nuclear-cytoplasmic compartmentalization of the herpes simplex virus 1 infected cell transcriptome is co-ordinated by the viral endoribonuclease vhs and cofactors to facilitate the translation of late proteins

K. Pheasant, C. S. Möller-Levet, J. Jones, D. Depledge, J. Breuer, G. Elliott

This study reveals that HSV1's vhs endoribonuclease, along with cofactors VP22 and VP16, coordinates nuclear-cytoplasmic compartmentalization of the infected cell transcriptome to regulate late protein translation.

bioRxiv · Sep 12, 2018Microbiology

Genomic and proteomic analysis of Human herpesvirus 6 reveals distinct clustering of acute versus inherited forms and reannotation of reference strain

A. Greninger, G. Knudsen, P. Roychoudhury, D. Hanson, R. A. Hall Sedlak, H. Xie, J. Guan, T. Nguyen, V. Peddu, M. Boeckh, M.-L. Huang, L. Cook, D. Depledge, D. Zerr, D. Koelle, , K. Jerome

This study sequences HHV-6B and iciHHV-6 genomes, identifies geographic clustering and recombination in active infections, and reannotates the HHV-6B genome using transcriptomics and proteomics.

bioRxiv · Aug 27, 2017Microbiology