Pulsed low-dose-rate radiation (PLDR) reduces the tumor-promoting responses induced by conventional chemoradiation in pancreatic cancer-associated fibroblasts
J. Franco-Barraza, T. Luong, J. K. Wong, K. Raghavan, E. Handroff, D. B. Vendramini-Costa, R. Francescone, J. C. Gardiner, J. E. Meyer, E. Cukierman
This study shows that pulsed low-dose-rate radiation combined with chemotherapy shifts pancreatic cancer-associated fibroblasts from tumor-promoting to tumor-suppressing, reducing desmoplasia and improving neoadjuvant therapy.
bioRxiv · Jan 13, 2024 · PreprintCancer Biology