S. Srinivasan

CREB drives acinar cells to ductal reprogramming and promotes pancreatic cancer progression in preclinical models of alcoholic pancreatitis

This study shows CREB promotes acinar-to-ductal reprogramming and pancreatic cancer progression in alcoholic pancreatitis models by enhancing fibrosis and tumor growth.

Monocytes Mobilized by Gut Neurons Remodel the Enteric Nervous System

The paper identifies that post-inflammatory GI dysmotility results from ENS remodeling driven by monocyte recruitment and neuroinflammation, which can be prevented by enhancing HIF1 signaling in enteric neurons.

Mitochondrial Raf1 Regulates Glutamine Catabolism

This paper identifies Raf1 within mitochondria where it interacts with GLS to regulate glutamine catabolism and tumorigenesis, independent of MAPK signaling.

Association of Macular Pigment Density with Plasma Macular Carotenoids levels, And lipids in Indian patients with early Age-Related Macular Degeneration

The paper examines the relationship between macular pigment optical density and plasma carotenoids and lipids in Indian patients with early AMD, finding a positive association between MPOD and plasma L, Z, and L+Z.

Targeting PKC alleviates iron overload in diabetes and hemochromatosis

This study shows PKC inhibition reduces iron overload in diabetes and hemochromatosis by modulating ferroportin expression and trafficking.

Unbiased MD simulations characterize lipid binding pockets in lipid transfer proteins

This study uses unbiased MD simulations to identify lipid binding pockets in LTPs, providing insights into lipid entry pathways for bridge-like LTPs.

Assembly reactions of SARS-CoV-2 nucleocapsid protein with nucleic acid

This study investigates the assembly of SARS-CoV-2 nucleocapsid protein with nucleic acids using biophysical techniques and mutant proteins, revealing key interaction motifs and stabilization mechanisms.

Modulation of Biophysical Properties of Nucleocapsid Protein in the Mutant Spectrum of SARS-CoV-2

The paper examines how mutations in SARS-CoV-2 nucleocapsid protein's intrinsically disordered regions affect its biophysical properties across different variants.

A homeostatic gut-to-brain insulin antagonist restrains neuronally stimulated fat loss

The paper identifies INS-7, an ancestral insulin superfamily peptide in C. elegans, as a gut-to-brain signal that counteracts neuronally driven fat loss during fasting.

Bamboozling Interactions: Interspecific associations within mixed-species bird flocks in bamboo in the Eastern Himalaya

The paper compares mixed-species bird flocks in bamboo and rainforest habitats, finding bamboo flocks more cohesive and interconnected, likely driven by resource availability and foraging behavior.

EX VIVO GENE EDITING AND CELL THERAPY FOR HEREDITARY TYROSINEMIA TYPE 1

This study develops an ex vivo CRISPR gene editing protocol for hepatocytes to treat hereditary tyrosinemia type 1, showing successful engraftment and disease correction in mice.

Spatially distinct inputs modulate the amount of active Mitotic-phase GAP to locally restrict RhoA signaling for successful cell division

The paper identifies two spatially distinct regulatory inputs that modulate MP-GAP activity to restrict RhoA signaling at cell poles and equator during cytokinesis.

A Vibrating Ingestible BioElectronic Stimulator Modulates Gastric Stretch Receptors for Illusory Satiety

The paper develops an ingestible device that activates gastric stretch receptors to reduce food intake and weight gain in swine.

Differences in Hepatocellular Iron Metabolism Underlie Sexual Dimorphism in Hepatocyte Ferroptosis

This study identifies sex differences in hepatocyte ferroptosis, showing males are more susceptible due to differences in iron metabolism and FSP1 regulation.

Small RNA Sequencing Reveals a Distinct MicroRNA Signature between Glucocorticoid Responder and Glucocorticoid Non-responder Primary Human Trabecular Meshwork Cells after Dexamethasone Treatment

CyVerse: Cyberinfrastructure for Open Science

The paper describes CyVerse, an open-source cyberinfrastructure platform for life sciences, and outlines a strategic blueprint for managing SaaS and IaC as free and open-source software.

Rescaling protein-protein interactions improves Martini 3 for flexible proteins in solution

This study improves the Martini 3 model by reducing protein-protein interaction strength, enhancing accuracy for flexible proteins in solution and with lipid membranes.

Conformational dynamics of lipid transfer domains provide a general framework to decode their functional mechanism.

This study uses molecular simulations to show that lipid transfer domains (LTDs) from different LTP families share conserved dynamical features that correlate with their functional mechanism.

SQ3370, the first clinical click chemistry-activated cancer therapeutic, shows safety in humans and translatability across species

This paper demonstrates SQ3370, a click chemistry-activated cancer therapeutic, is safe in humans and shows translatability across species with effective tumor activation and immune response.

Click chemistry selectively activates an auristatin protodrug with either intratumoral or systemic tumor-targeting agents

This paper demonstrates the activation of a protodrug, SQP22, using click chemistry with tumor-targeting agents, showing anti-tumor effects in murine models with reduced toxicity.

Identification of a Micropeptide Linked to Cancer Stem Cell Regulation and Chemoresistance

This study identifies IRX4_PEP1, a micropeptide from IRX clusters, as a regulator of prostate cancer stem cells and chemoresistance, with potential as a therapeutic target and biomarker.

The Dietary Fermentable Fiber Inulin Alters the Intestinal Microbiome and Improves Chronic Kidney Disease Mineral-Bone Disorder in a Rat Model of CKD

This study shows that adding inulin to the diet of CKD rats changes gut microbiota, lowers uremic toxins, and improves CKD-MBD parameters like bone and cardiovascular health.

Poles apart: the structure and composition of the bird community in bamboo in the Eastern Himalaya

This study examines bird and arthropod communities in bamboo and rainforest in the Eastern Himalaya, finding distinct community compositions and evidence of bamboo-specialist bird species.

Two unique biological response-modifier glucans beneficially regulating gut microbiota and faecal metabolome in a non-alcoholic steatohepatitis animal model, with potential for applications in human health and disease

This study evaluates the effects of two glucans on gut microbiota and metabolome in a NASH model, showing beneficial changes in microbial composition and metabolite levels.

Absorbable Conductive Electrotherapeutic Scaffolds (ACES) for Enhanced Peripheral Nerve Regeneration and Stimulation

This paper introduces ACES, absorbable conductive scaffolds that enhance peripheral nerve regeneration and stimulation in animal models.

Editing the core region in HPFH deletions alters fetal and adult globin expression for treatment of β-hemoglobinopathies

This study edits the PRR-βE1 region in HSPCs to suppress HbA and enhance HbF production, showing therapeutic benefits for β-hemoglobinopathies.

Induced ligno-suberin vascular coating and tyramine-derived hydroxycinnamic acid amides restrict Ralstonia solanacearum colonization in resistant tomato roots

This study identifies structural barriers in resistant tomato roots that restrict Ralstonia solanacearum colonization and slow disease progression.

Ligand-induced transmembrane conformational coupling in monomeric EGFR

This study shows ligand binding causes intracellular conformational changes in monomeric EGFR, linking extracellular and intracellular regions through the transmembrane helix.

A basement membrane discovery pipeline uncovers network complexity, new regulators, and human disease associations

The paper develops a pipeline to identify BM-associated proteins, finds new regulators, and links BM genes to human disease.

Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling

This study determines the structure of ROR2's CRD and Kr domains, revealing a novel mechanism for WNT5A signaling and identifying the CRD's role in ROR2 function and secretion.