Viral Insulin/IGF-like Peptides Selectively Activate Host Insulin/IGF Signaling pathways during Grouper Iridovirus Infection
A. CHUARD, K. Nesarajah, K. Danazumi, K. Reiners, F. Zhang, L. Levintov, H. Vashisth, R. DiMarchi, E. Altindis
This study identifies GIV-VILP as a viral mimic of host insulin/IGF-1 that selectively activates the Akt/PI3K pathway during infection, enhancing viral replication.
bioRxiv · Jun 13, 2024 · PreprintMicrobiology