F. Zhang

Origin and stepwise improvement of vertebrate lungs

The paper analyzes single-cell RNA sequencing data to show that lung development involves regulatory changes and new genes, with some features specific to bony fishes and mammals.

A smartphone-based genetically recombinant whole-cell biosensor for highly sensitive monitoring of polychlorinated biphenyls (PCBs)

This paper develops a genetically engineered whole-cell biosensor using E. coli to detect multiple PCB congeners with high sensitivity, and integrates it with a smartphone for real-time monitoring.

Viral Insulin/IGF-like Peptides Selectively Activate Host Insulin/IGF Signaling pathways during Grouper Iridovirus Infection

This study identifies GIV-VILP as a viral mimic of host insulin/IGF-1 that selectively activates the Akt/PI3K pathway during infection, enhancing viral replication.

Horizontally acquired CSP genes contribute to wheat adaptation and improvement

This study identifies horizontally acquired CSP genes in wheat that enhance drought tolerance and photosynthetic efficiency, contributing to wheat adaptation and improvement.

The genomic and epigenomic dynamics of hemizygous genes across crops with contrasting mating systems

This study examines hemizygous genes in 22 crop genomes, finding higher hemizygosity in clonal lineages and distinct expression and epigenetic features compared to diploid genes.

A genome-scale screen identifies sulfated glycosaminoglycans as pivotal in epithelial cell damage by Candida albicans

This study identifies sulfated glycosaminoglycans as targets of candidalysin, a virulence factor in C. albicans, and shows that blocking these interactions can protect epithelial cells from fungal damage.

Granzyme K drives a newly-intentified pathway of complement activation

This study identifies granzyme K as a driver of a novel complement activation pathway independent of classical, lectin, or alternative pathways.

Phenotypic variability between closely related Trichodesmium strains as a means to making the most out of heterogeneous microenvironments

The paper investigates phenotypic variability among Trichodesmium strains in heterogeneous microenvironments using metagenomics and metatranscriptomics.

Characterizing interactions of ER resident proteins in situ through the YST-PPI method

The paper introduces YST-PPI, a method to study ER resident protein interactions in situ, identifies 74 protein pairs, and highlights Lhs1p's role in regulating these interactions.

Adipocyte microRNA-802 promotes adipose tissue inflammation and insulin resistance by modulating macrophages in obesity

This study shows that miR-802 in adipose tissue promotes inflammation and insulin resistance by modulating macrophage recruitment and polarization in obesity.

A Combinatorial Strategy for HRV 3C Protease Engineering to Achieve the N-terminal Free Cleavage

This paper develops a combinatorial strategy to engineer HRV 3C protease for N-terminal free cleavage by expanding P1 specificity through structure-guided library design and high-throughput screening.

Deep learning based genomic breeding of pest-resistant grapevine

This study uses deep learning and genome-wide association studies to identify pest-resistant genes in grapevine, achieving high accuracy in predicting pest damage.

Targeting G9a translational mechanism of SARS-CoV-2 pathogenesis for multifaceted therapeutics of COVID-19 and its sequalae

This paper identifies G9a's role in SARS-CoV-2-induced pathogenesis by regulating translation of viral and host proteins, showing that G9a inhibitors can reverse disease-related proteomic changes.

Brain-wide neuronal circuit connectome of human glioblastoma

This study shows human glioblastoma cells integrate into brain-wide neuronal circuits, exhibit diverse connectivity, and respond to neuromodulatory inputs like acetylcholine, which promotes invasion and survival.

Systemically targeting monocytic MDSCs using dendrimers and their cell-level biodistribution kinetics

This study examines how hydroxyl dendrimers are taken up by M-MDSCs in tumor and lymphoid organs, showing differential uptake based on dendrimer functionality and serum proteins.

A new story of four Hexapoda classes: Protura as the sister to all other hexapods

This study resolves the phylogenetic relationships of early hexapods, finding Protura as the earliest-diverging lineage and supporting a new classification of hexapod evolution.

An Efficient and Safe Trans-complementation System for MPXV Mimicking Authentic Viral Infection

This paper develops a safe trans-complementation system for MPXV that mimics authentic infection, enabling research in lower biosafety labs without live virus.

Senolytics enhance longevity in Caenorhabditis elegans by altering betaine metabolism

This study identifies betaine metabolism as a key factor in aging in C. elegans and shows that senolytics extend lifespan by increasing betaine levels and enhancing autophagy and antioxidant capacity.

Filter-aided expansion proteomics

The paper introduces FAXP, a method combining hydrogel expansion and mass spectrometry for high-resolution proteomics of FFPE tissues, showing improved resolution and efficiency over existing methods.

Quantitative Profiling Method for Oxylipins in Neurodegenerative Diseases by Liquid Chromatography Coupled with Tandem Mass Spectrometry

This paper develops a method to measure CYP-EH PUFA metabolites in C. elegans using UPLC-MS/MS, showing similar metabolites to mammals and demonstrating changes with EH inhibition.

A genome-wide CRISPR/Cas9 screen identifies genes that regulate the cellular uptake of α-synuclein fibrils by modulating heparan sulfate proteoglycans

This study uses CRISPR/Cas9 screening to identify genes regulating α-synuclein fibril uptake via heparan sulfate proteoglycans, revealing SLC39A9 and C3orf58 as key modulators.

Comparative single-cell regulome reveals evolutionary innovations in neural progenitor cells during primate corticogenesis

The paper compares single-cell regulomes of macaque and mouse neural progenitors with human data to identify evolutionary changes in cortex development.

Sirenian genomes illuminate the evolution of fully aquatic species within the mammalian superorder Afrotheria

This study analyzes sirenian genomes to identify genomic adaptations to aquatic life and conservation challenges.

Detection and characterization of a novel bat filovirus (Dehong virus, DEHV) in fruit bats

The paper detects and characterizes a novel bat filovirus, Dehong virus (DEHV), from Rousettus leschenaultii bats, placing it phylogenetically between Dianlovirus and Marburgvirus.

BrrRCO, encoding a homeobox protein, is involved in leaf lobe development in Brassica rapa

This study identifies BrrRCO, a HD-Zip transcription factor, as a key gene regulating leaf lobe development in Brassica rapa, with cis-regulatory variations affecting its function and leaf shape.

SARS-CoV-2 spike glycosylation affects function and neutralization sensitivity

This study examines how SARS-CoV-2 spike glycosylation affects viral function and neutralization sensitivity to antibodies.

Co-occurrence of ST412 Klebsiella pneumoniae isolates with hypermucoviscous and no-mucoviscous phenotypes in a short-term hospitalized patient

This study identifies co-occurrence of hypermucoviscous and non-hypermucoviscous K. pneumoniae phenotypes in a clonal population, linked to specific mutations and metabolic gene dysregulation.

ABI1 regulates transcriptional activity of Androgen Receptor by novel DNA and AR binding mechanism

This paper identifies ABI1 as an epigenetic regulator of transcriptional homeostasis in AR-driven cancers through novel DNA and AR binding mechanisms.

Carcinogenesis is associated with sex-biased tissue environments and imbalances between estrogen receptor alpha and thyroid hormone receptors

This study identifies sex-biased tissue environments and hormonal receptor imbalances as factors influencing cancer incidence patterns and carcinogenesis direction.

The first complete mitochondrial genome of Sphaeniscus atilius (Walker, 1849) (Diptera: Tephritidae) and implications for the phylogenetic relationships of Tephritidae

This study characterizes the first complete mitochondrial genome of Sphaeniscus atilius and presents phylogenetic insights for Tephritidae family relationships.