Attenuation of chronic antiviral T cell responses through constitutive COX2-dependent prostanoid synthesis by lymph node fibroblasts
K. Schaeuble, H. Cannelle, S. Favre, H.-Y. Huang, S. Oberle, D. Zehn, S. A. Luther
The paper identifies lymph node fibroblastic reticular cells (FRC) as a source of COX2-dependent PGE2 that suppresses T cell responses during chronic infection.
bioRxiv · Oct 30, 2018Immunology