H.-Y. Huang

This study identifies OPCs and punicalagin as potent inhibitors of SARS-CoV-2 infection, with punicalagin showing the strongest activity against omicron variants and viral entry.

The paper reports a cryo-EM structure of a PmrA-dependent transcription activation complex and shows how PmrA interacts with DNA and RNA polymerase to activate gene transcription.

This study shows that trimming N-glycans from the SARS-CoV-2 spike protein enhances immune responses and protection against variants in hACE2 mice.

This study shows that PTP-3 promotes intramolecular folding of SYD-2, reducing its interaction with UNC-104 and slowing axonal transport in C. elegans neurons.

This study identifies BCAT1-mediated metabolic reprogramming as a mechanism of EGFR TKI resistance in lung cancer and shows that combining TKI with ROS-inducing agents can overcome resistance.

This study shows that pathogen-induced pH changes regulate plant growth and defense by modulating cellulose synthesis and fungal pathogenicity through COMPANION OF CELLULOSE SYNTHASE proteins.

The paper identifies lymph node fibroblastic reticular cells (FRC) as a source of COX2-dependent PGE2 that suppresses T cell responses during chronic infection.