Identification of the KIF18A alpha-4 helix as a therapeutic target for chromosomally unstable tumor cells
K. Schutt, K. A. Queen, K. Fisher, O. Budington, W. Mao, W. Liu, Y. Xiao, F. Aswad, J. Joseph, J. Stumpff
This study identifies the KIF18A alpha-4 helix as a therapeutic target, showing that mutations or inhibitors targeting this region disrupt proliferation of chromosomally unstable tumor cells.
bioRxiv · Oct 16, 2023 · PreprintCancer Biology