J. Joseph

The evolution of GC-biased gene conversion by means of natural selection

This study shows that GC-biased gene conversion (gBGC) evolves under weak stabilising selection and can increase population load, suggesting it may have been positively selected in humans.

Single Cell Analysis of Peripheral TB-Associated Granulomatous Lymphadenitis

This study uses scRNA-seq to analyze granulomatous lymph nodes from TB patients, identifying cell types, signaling networks, and Mtb RNA detection in infected cells.

Green Jackfruit Flour Prevents Metabolic Dysfunction-Associated Steatohepatitis and Progression to Hepatocellular Carcinoma via the AMPK and MAPK Signaling Pathways

This study shows that green jackfruit flour reduces MASH and HCC in mice by activating AMPK and inhibiting MAPK pathways through microbial fermentation products.

A Mechanically Resilient Soft Hydrogel Improves Drug Delivery for Treating Post-Traumatic Osteoarthritis in Physically Active Joints

This paper develops a mechanically resilient hydrogel for drug delivery in physically active joints, showing sustained release and reduced cartilage degeneration in a mouse model of post-traumatic osteoarthritis.

Palynological studies on selected members of Fabaceae

This study assesses pollen viability and germination in selected Fabaceae species using in vitro methods, revealing significant variation among species.

PRDM9 drives the location and rapid evolution of recombination hotspots in salmonids

This study identifies PRDM9's role in driving recombination hotspots in salmonids, showing rapid evolution and conservation of its function across vertebrates.

Increased positive selection in highly recombining genes is not an evidence for an evolutionary advantage of recombination

The paper shows that increased positive selection in highly recombining genes is not due to more effective selection but rather to gBGC-driven fixation of beneficial mutations.

Comprehensive Codon Usage Analysis Across Diverse Plant Lineages

This study analyzes codon usage patterns across plant lineages, finding that vascularization influences codon usage more than seed production and identifying dinucleotide biases across species.

Ultra-Long-Term Delivery of Hydrophilic Drugs Using Injectable In Situ Cross-Linked Depots

This paper develops an injectable platform for ultra-long-term hydrophilic drug delivery, achieving sustained release over six months in vivo.

Identification of the KIF18A alpha-4 helix as a therapeutic target for chromosomally unstable tumor cells

This study identifies the KIF18A alpha-4 helix as a therapeutic target, showing that mutations or inhibitors targeting this region disrupt proliferation of chromosomally unstable tumor cells.

A Drug-Free Pathogen Capture and Neutralizing Nasal Spray to Prevent Emerging Respiratory Infections

This paper introduces a drug-free nasal spray that captures and neutralizes respiratory pathogens, showing high efficacy in mice against influenza.

Bioinformatic and Experimental Characterization of the RBM15 RNA Binding Protein

This study characterizes RBM15's RNA binding mechanism through bioinformatics and experiments, showing it interacts with stem-loop RNA motifs via RRMs 2 and 3.

In Vivo Monitoring of Cellular Senescence by Photoacoustic and Fluorescence Imaging Utilizing a Nanostructured Organic Probe

This study develops a nanostructured organic probe, NanoJaggs, for in vivo monitoring of cellular senescence using photoacoustic and fluorescence imaging, showing specificity for chemotherapy-induced senescence in tumors.

Development and Optimisation of in vitro Sonodynamic Therapy for Glioblastoma

The paper develops an automated in vitro sonodynamic therapy system for glioblastoma and demonstrates its efficacy in inducing apoptosis and reducing 3D growth of glioma cells.

Estimating the proportion of beneficial mutations that are not adaptive in mammals

The paper estimates the proportion of beneficial mutations in mammals that are not adaptive, finding they account for 15-45% of all beneficial mutations in 24 of 28 populations.

PhylteR: efficient identification of outlier sequences in phylogenomic datasets

PhylteR identifies outlier sequences in phylogenomic datasets using DISTATIS, improving gene tree concordance with species trees.

Decoding Proteoforms with Single Acid Resolution Using a Sub-nanometer Diameter Pore

The paper demonstrates that sub-nanopore assays can decode proteoforms with single acid resolution by analyzing current fluctuations correlated with amino acid volumes and PTMs.

Post-vaccination Omicron infections induce broader immunity across antigenic space than prototype mRNA COVID-19 booster vaccination or primary infection

The paper compares antibody responses to different SARS-CoV-2 variants after vaccination and infection, finding that post-vaccination Omicron infection induces broader immunity than triple vaccination alone.

Green tea and Spirulina extracts inhibit SARS, MERS, and SARS-2 spike pseudotyped virus entry in vitro

A novel innate pathogen sensing strategy involving ubiquitination of bacterial surface proteins

The paper identifies a novel innate pathogen sensing strategy through ubiquitination of bacterial surface proteins, revealing a conserved mechanism for pathogen detection and clearance.

Kinetic interplay between droplet maturation and coalescence modulates shape of aged protein condensates

This study develops a coarse-grained model to investigate how changes in protein interaction strength during condensate maturation affect their shape and solid-like properties over time.

Nup358 regulates remodelling of ER-mitochondrial contact sites and autophagy

This study shows that Nup358 regulates ER-mitochondria contact sites dynamics and autophagy by modulating mTORC2/Akt signaling and Ca2+ release.

Design of a highly thermotolerant, immunogenic SARS-CoV-2 spike fragment

This paper designs a thermotolerant, immunogenic SARS-CoV-2 RBD protein fragment that is stable at high temperatures and elicits neutralizing antibodies in guinea pigs.

DNA-based nanocarriers to enhance the optoacoustic contrast of tumors in vivo

This study introduces DNA-based nanocarriers to improve optoacoustic tumor imaging by enhancing signal generation and prolonging circulation time of near infrared dyes.

Acute decrease in plasma membrane tension induces macropinocytosis via PLD2 activation

The paper shows that acute plasma membrane tension decrease triggers macropinocytosis through PLD2 activation and phosphatidic acid production in myoblasts.

Evidence for absence of bilateral transfer of olfactory learned information in Apis dorsata and Apis mellifera

The paper shows that honeybees cannot transfer olfactory memory between brain hemispheres, indicating independent memory storage and retrieval in each side.

Metagenomic Insights Unveil the Dominance of Undescribed Actinobacteria in Pond Ecosystem of an Indian Shrine

The paper uses metagenomic analysis to identify Actinobacteria in pond sediment, revealing many undescribed species with potential pharmaceutical applications.

Cytoskeletal mechanisms of axonal contractility

This study investigates cytoskeletal mechanisms regulating axonal contractility, finding that actomyosin drives active contraction while microtubules have a secondary role.

Azithromycin reduces systemic inflammation and provides survival benefit in murine model of polymicrobial sepsis

This study shows that azithromycin combined with ceftriaxone improves survival in a murine sepsis model by reducing inflammation, not by antibacterial effects.

Photoacoustic molecular rulers based on DNA nanostructures

This paper demonstrates the use of photoacoustic tomography to measure distance-dependent FRET in DNA nanostructures at centimeter depths, validating their potential to enhance photoacoustic signal generation.