K. Swovick

Formylation facilitates the reduction of oxidized initiator methionines

This study shows that formylation of initiator methionines enhances their enzymatic reduction and mitigates oxidation-related misprocessing.

Proteome birthdating reveals age-selectivity of protein ubiquitination

This study introduces proteome birthdating to measure protein age and finds that ubiquitinated proteins are predominantly newly synthesized, with distinct age distributions across cellular pathways.

Methionine Alkylation as an Approach to Quantify Methionine Oxidation Using Mass Spectrometry

This paper introduces MObBa, a mass spectrometry method to quantify methionine oxidation by alkylating unoxidized methionines, enabling accurate measurement of oxidation levels in peptides and proteomes.

Long lifetime and selective accumulation of the A-type lamins accounts for the tissue specificity of Hutchinson-Gilford progeria syndrome

This study shows that the long lifetime and selective accumulation of A-type lamins in specific tissues explain the tissue specificity of Hutchinson-Gilford progeria syndrome.

Folding stabilities of ribosome-bound nascent polypeptides probed by mass spectrometry

This study uses mass spectrometry to measure how ribosome binding affects the folding stability of nascent polypeptides, finding that ribosome-induced stability changes depend on localized charge distributions.