Author

A. Seluanov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Evolutionary Biology· 3 Biochemistry· 2 Immunology· 2 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Organism:mouse· 6 Research Focus:cell type annotation· 4 Research Focus:development & morphogenesis· 4 Research Focus:differential expression· 4 Assay:DNA methylation· 4 Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 3

Frequent Co-Authors

V. Gorbunova· 12 shared V. N. Gladyshev· 6 shared Z. Zhang· 5 shared S. Emmrich· 4 shared S. Horvath· 4 shared A. Haghani· 3 shared A. Trapp· 3 shared X. Tian· 3 shared

Activity by Year

2019-2023 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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12 shared papersCell Biology

V. Gorbunova

Mutual co-authors in cluster

Author profile →

12 papers

Recent·Most cited

Linked regulation of genome integrity and senescence-associated inflammation by p53

K. N. Miller, B. Li, H. R. Pierce-Hoffman, S. Patel, X. Lei, A. Rajesh, M. G. Teneche, A. P. Havas, A. Gandhi, C. Cano Macip, J. Lyu, S. G. Victorelli, S.-H. Woo, A. B. Lagnado, M. A. LaPorta, , P. D. Adams

This study identifies a mitochondria-regulated p53 circuit that links genomic instability and inflammation in senescent cells, showing p53 suppresses inflammation without affecting cell cycle arrest.

bioRxiv · Nov 20, 2023 · PreprintCell Biology

Epigenetic predictors of species maximum lifespan and other life history traits in mammals

C. Z. Li, A. Haghani, Q. Yan, A. T. Lu, J. Zhang, Z. Fei, J. Ernst, X. Yang, V. N. Gladyshev, K. Raj, A. Seluanov, V. Gorbunova, S. Horvath

The paper develops DNA methylation predictors for mammalian maximum lifespan, gestation time, and sexual maturity, showing species-level epigenetic signatures that differ from individual lifespan variation.

bioRxiv · Nov 2, 2023 · PreprintEvolutionary Biology

Proteome birthdating reveals age-selectivity of protein ubiquitination

M. E. Meadow, S. Broas, M. Hoare, F. Alimohammadi, K. A. Welle, K. Swovick, J. R. Hryhorenko, J. C. Martinez, S. A. Biashad, A. Seluanov, V. Gorbunova, A. Buchwalter, S. Ghaemmaghami

This study introduces proteome birthdating to measure protein age and finds that ubiquitinated proteins are predominantly newly synthesized, with distinct age distributions across cellular pathways.

bioRxiv · Oct 8, 2023Biochemistry

Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging.

P. T. Paine, C. Rechsteiner, F. Morandini, G. Desdin Mico, C. Mrabti, A. Parras, A. Haghani, R. Brooke, S. Horvath, A. Seluanov, V. Gorbunova, A. Ocampo

The paper uses partial cellular reprogramming to reduce DNA damage in an ERCC1 mouse model of premature aging, showing restoration of the epigenetic clock and DNA repair processes.

bioRxiv · May 12, 2023Cell Biology

Evolution of High-Molecular-Mass Hyaluronic Acid is Associated with Subterranean Lifestyle

Y. Zhao, Z. Zheng, Z. Zhang, E. Hillpot, Y. S. Lin, F. T. Zakusilo, J. Y. Lu, J. Ablaeva, R. A. Miller, E. Nevo, A. Seluanov, V. Gorbunova

The paper identifies that subterranean mammals have abundant high-molecular-mass HA due to genetic changes, which may aid in cancer resistance and adaptation to hypoxic environments.

bioRxiv · May 8, 2023Evolutionary Biology

Increased hyaluronan by naked mole-rat HAS2 extends lifespan in mice

Z. Zhang, X. Tian, J. Y. Lu, K. Boit, J. Ablaeva, F. T. Zakusilo, S. Emmrich, D. Firsanov, E. Rydkina, S. A. Biashad, Q. Lu, A. Tyshkovskiy, V. N. Gladyshev, S. Horvath, A. Seluanov, V. Gorbunova

This study shows that overexpressing the naked mole-rat HAS2 gene in mice increases hyaluronan levels, reduces inflammation, and extends lifespan and healthspan.

bioRxiv · May 4, 2023 · PreprintPhysiology

Accurate proteome-wide measurement of methionine oxidation in aging mouse brains

J. Q. Bettinger, M. Simon, A. Korotov, K. A. Welle, J. R. Hryhorenko, A. Seluanov, V. Gorbunova, S. Ghaemmaghami

This study introduces a method to measure methionine oxidation in mouse brains and finds that oxidation is consistent across individuals but not significantly altered with age.

bioRxiv · Feb 19, 2022 · PreprintBiochemistry

Naked mole-rat hematopoietic stem and progenitors are highly quiescent with an inherent myeloid bias

S. Emmrich, A. Trapp, F. Tolibzoda Zakusilo, M. Mariotti, M. E. Straight, Z. Zhang, S. Gray, M. G. Drage, Z. Ke, M. Takasugi, J.-H. Klusmann, V. N. Gladyshev, A. Seluanov, V. Gorbunova

This study identifies unique hematopoietic features in naked mole-rats, including myeloid bias and quiescent stem cells, linked to their exceptional longevity.

bioRxiv · Aug 1, 2021Cell Biology

Ectopic cervical thymi and no thymic involution until midlife in naked mole-rats

S. Emmrich, F. Tolibzoda Zakusilo, A. Trapp, X. Zhou, Q. Zhang, E. M. Irving, M. G. Drage, Z. Zhang, V. N. Gladyshev, A. Seluanov, V. Gorbunova

This study shows that naked mole-rats lack thymic involution until midlife and have ectopic cervical thymi with distinct T cell composition compared to mice.

bioRxiv · Aug 1, 2021Immunology

DNA Methylation Networks Underlying Mammalian Traits

A. Haghani, A. T. Lu, C. Z. Li, T. R. Robeck, K. Belov, C. E. Breeze, R. T. Brooke, S. Clarke, C. G. Faulkes, Z. Fei, S. H. Ferguson, C. J. Finno, V. N. Gladyshev, V. Gorbunova, R. G. Goya, , S. Horvath

This study analyzes DNA methylation across 11,117 samples from 176 species to identify modules related to traits like age, lifespan, and phylogeny, revealing epigenetic patterns across evolution and aging.

bioRxiv · Mar 16, 2021Evolutionary Biology

Dampened PI3K/AKT signaling contributes to cancer resistance of the naked mole rat

J. Zhao, X. Tian, Y. Zhu, Z. Zhang, E. Rydkina, Y. Yuan, H. Zhang, B. Roy, A. Cornwell, E. Nevo, X. Shang, R. Huang, K. Kristiansen, A. Seluanov, X. Fang, V. Gorbunova

This study compares transcriptional responses to oncogenes in cancer-resistant and -prone species, finding that naked mole rat cells resist Ras-induced changes due to dampened PI3K/AKT signaling.

bioRxiv · Feb 27, 2020 · PreprintCancer Biology

The hematopoietic landscape at single-cell resolution reveals unexpected stem cell features in naked mole-rats

S. Emmrich, M. Mariotti, M. Takasugi, M. E. Straight, A. Trapp, V. N. Gladyshev, A. Seluanov, V. Gorbunova

This study profiles the hematopoietic system of naked mole-rats at single-cell resolution, revealing unique stem cell features associated with longevity and cancer resistance.

bioRxiv · Nov 29, 2019 · PreprintImmunology