S. Ghaemmaghami

This study introduces proteome birthdating to measure protein age and finds that ubiquitinated proteins are predominantly newly synthesized, with distinct age distributions across cellular pathways.

This paper introduces MObBa, a mass spectrometry method to quantify methionine oxidation by alkylating unoxidized methionines, enabling accurate measurement of oxidation levels in peptides and proteomes.

This study shows that the long lifetime and selective accumulation of A-type lamins in specific tissues explain the tissue specificity of Hutchinson-Gilford progeria syndrome.

This study uses mass spectrometry to measure how ribosome binding affects the folding stability of nascent polypeptides, finding that ribosome-induced stability changes depend on localized charge distributions.

This study introduces a method to measure methionine oxidation in mouse brains and finds that oxidation is consistent across individuals but not significantly altered with age.

The paper shows that oxidation rates of buried methionines correlate with protein folding stability, using E. coli and T. thermophilus proteomes to demonstrate this relationship.

This study identifies miR-574 as a regulator of FAM210A, which influences mitochondrial protein expression and cardiac remodeling in heart failure.

This study shows that redox regulation controls TDP43 low complexity domain aggregation into cross-β polymers, with implications for neurodegenerative diseases.

This study develops a method to quantify methionine oxidation in the human proteome by isotopic labeling and validates it using artificial proteomes, identifying novel in vivo oxidation sites.

This study quantifies how prion infection affects protein degradation rates in N2a cells, finding increased degradation kinetics for most proteins and reduced prion protein degradation.

The paper quantifies protein folding stabilities in human cell extracts using methionine oxidation rates, identifying stable ontological subsets and showing stability impacts oxidation and TMAO effects.

This study investigates whether sirtuin-mediated acetylation regulates 2-HG production by metabolic enzymes, finding no direct link between enzyme acetylation and 2-HG generation.