Wnt/PCP signaling mediates breast cancer metastasis by promoting pro-invasive protrusion formation in collectively motile leader cells
K. VanderVorst, C. Dreyer, J. Hatakeyama, G. R. Bell, A. L. Berg, M. Hernandez, H. Lee, S. R. Collins, K. L. Carraway
This study shows Wnt/PCP signaling promotes breast cancer metastasis by enhancing pro-invasive protrusions in leader cells during collective migration.
bioRxiv · Jan 7, 2022 · PreprintCancer Biology