K. Zinovjev

4-Thiaproline accelerates the slow folding phase of proteins containing cis prolines in the native state by two orders of magnitude

This study shows that 4-thiaproline accelerates the refolding of proteins with cis proline residues by two orders of magnitude without affecting thermodynamic stability or enzymatic activity.

Tautomer-specific deacylation and {Omega}-loop flexibility explain carbapenem-hydrolyzing, broad-spectrum activity of the KPC-2 β-lactamase

This study identifies how tautomer-specific deacylation and {Omega}-loop flexibility enable KPC-2 β-lactamase to efficiently hydrolyze carbapenems, revealing structural and energetic mechanisms for its broad-spectrum activity.