Author

P. Hinchliffe

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Biology Disciplines

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Biochemistry· 1

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Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

A. J. Mulholland· 1 shared C. J. Schofield· 1 shared C. K. Colenso· 1 shared C. L. Tooke· 1 shared J. Spencer· 1 shared K. Zinovjev· 1 shared M. Beer· 1 shared

Activity by Year

2022-2022 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

A. J. Mulholland

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1 paper

Recent·Most cited

Tautomer-specific deacylation and {Omega}-loop flexibility explain carbapenem-hydrolyzing, broad-spectrum activity of the KPC-2 β-lactamase

C. L. Tooke, P. Hinchliffe, M. Beer, K. Zinovjev, C. K. Colenso, C. J. Schofield, A. J. Mulholland, J. Spencer

This study identifies how tautomer-specific deacylation and {Omega}-loop flexibility enable KPC-2 β-lactamase to efficiently hydrolyze carbapenems, revealing structural and energetic mechanisms for its broad-spectrum activity.

bioRxiv · Nov 11, 2022Biochemistry