Author

C. K. Colenso

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Approach:mechanistic / dynamical model· 1 Assay:protein sequence· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

A. J. Mulholland· 1 shared C. J. Schofield· 1 shared C. L. Tooke· 1 shared D. Cabezas-Bratesco· 1 shared D. Granata· 1 shared J. C. Opazo· 1 shared J. Spencer· 1 shared K. Zavala· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

A. J. Mulholland

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2 papers

Recent·Most cited

BiochemistrybioRxivNov 11, 2022

Tautomer-specific deacylation and {Omega}-loop flexibility explain carbapenem-hydrolyzing, broad-spectrum activity of the KPC-2 β-lactamase

C. L. Tooke, P. Hinchliffe, M. Beer…·J. Spencer

This study identifies how tautomer-specific deacylation and {Omega}-loop flexibility enable KPC-2 β-lactamase to efficiently hydrolyze carbapenems, revealing structural and energetic mechanisms for its broad-spectrum activity.

DOI 10.1021/jacs.2c12123

structural biologystatistical model

𝕏 PostBluesky

Evolutionary BiologybioRxivSep 6, 2021

Sequence conservation and structural features that are common within TRP channels

D. Cabezas-Bratesco, C. K. Colenso, K. Zavala…·S. E. Brauchi

The paper identifies a conserved residue fingerprint in TRP channels that may explain differences in coupling strategies among subgroups.

DOI 10.7554/elife.73645

protein sequencebiophysical modeling

𝕏 PostBluesky