HLJ1 amplifies endotoxin-induced sepsis severity by promoting IL-12 heterodimerization in macrophages
W.-J. Luo, S.-L. Yu, C.-C. Chang, M.-H. Chien, K.-M. Liao, Y.-L. Chang, Y.-H. Chuang, J. J. W. Chen, P.-C. Yang, K.-Y. Su
This study shows HLJ1 promotes IL-12 heterodimerization in macrophages, worsening sepsis severity, and suggests targeting HLJ1 could treat IL-12/IFN-γ-related diseases.
bioRxiv · Jan 5, 2022Immunology