ImmunologybioRxiv
HLJ1 amplifies endotoxin-induced sepsis severity by promoting IL-12 heterodimerization in macrophages
W.-J. Luo, S.-L. Yu, C.-C. Chang…·K.-Y. Su
This study shows HLJ1 promotes IL-12 heterodimerization in macrophages, worsening sepsis severity, and suggests targeting HLJ1 could treat IL-12/IFN-γ-related diseases.
DOI 10.7554/elife.76094