Author

Kai Wu

Chinese Academy of Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Biochemistry· 1 Developmental Biology· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

H. Eric XuiD· 2 shared Xinheng HeiD· 2 shared Aihua YiniD· 1 shared Bruno FrédérichiD· 1 shared Canrong WuiD· 1 shared Changyao LiiD· 1 shared David LecchiniiD· 1 shared Gaoming WangiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersMolecular Biology

H. Eric XuORCID

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Author profile →

4 papers

Recent·Most cited

Molecular architecture of OXGR1 reveals evolutionary conserved mechanisms for metabolite surveillance

Xinyue Zhang, Yujie Lu, Xinheng He, Shimeng Guo, Changyao Li, Yu Wang, Yuan Gao, Juxia Yao, Qingning Yuan, Yinshan Tang, Wen Hu, Zijuan Luo, Kai Wu, Yue Wang, Wanchao Yin, , Heng Liu

This study determines the cryo-EM structures of OXGR1 bound to metabolites, revealing conserved mechanisms for metabolite recognition and receptor activation.

The EMBO Journal · Jun 3, 2026Peer-reviewedMolecular Biology

Structural Insights into Selective and Dual Antagonism of EP2 and EP4 Prostaglandin Receptors

Yanli Wu, Heng Zhang, Jiuyin Xu, Kai Wu, Wen Hu, Xinheng He, Gaoming Wang, Canrong Wu, H. Eric Xu

The paper presents cryo-EM structures of EP2 and EP4 receptors with antagonists, revealing structural differences that explain selectivity and binding modes.

The EMBO Journal · Oct 29, 2025Peer-reviewedBiochemistry

The multi-level effect of chlorpyrifos during clownfish metamorphosis

Mathieu Reynaud, Stefano Vianello, Shu‐Hua Lee, Pauline Salis, Kai Wu, Bruno Frédérich, David Lecchini, Laurence Besseau A, Natacha Roux, Vincent Laudet

This paper investigates how chlorpyrifos exposure disrupts thyroid hormone signaling and metamorphosis in clownfish larvae, showing impaired white band formation and body shape changes, with TH treatment reversing some effects.

Molecular and Cellular Endocrinology · Apr 6, 2025Peer-reviewedDevelopmental Biology

Developmentally Delayed Epigenetic Reprogramming Underlying the Pathogenesis of Preeclampsia

Wei He, Yuan Wei, Xiaoli Gong, Luyuan Chang, Wan Jin, Ke Liu, Xinghuan Wang, Yu Xiao, Wenjing Zhang, Qiong Chen, Kai Wu, Lili Liang, Jia Liu, Ya–Wen Chen, Huanhuan Guo, , Aihua Yin

This study identifies epigenetic reprogramming defects in preeclampsia placenta that cause developmental delay and can be detected in serum cfDNA for early prediction.

bioRxiv · May 8, 2020 · PreprintGenomics