Yu Wang

The Cardiovascular Benefit of Menopause Hormone Treatment is Age-Dependent in Ldlr-/- Mice

This study shows that menopause hormone treatment (E2) reduces atherosclerosis in young mice but not older mice, due to age-related changes in inflammation and estrogen receptor signaling.

LineageFlow: Growth-Corrected State Dynamics for Probabilistic Cell-Fate Prediction

LineageFlow predicts clonal fate and transcriptional profiles by integrating growth dynamics and state transitions in single-cell lineage data.

A telomere-to-telomere genome of Holstein cattle resolves chromosome-end architecture and the genetic basis of telomere length

This paper presents a telomere-to-telomere genome of Holstein cattle, identifies genetic loci associated with telomere length, and highlights key biological processes involved.

A systematic delineation of 3' UTR regulatory elements and their contextual associations

The paper identifies 3'UTR regulatory elements using synthetic inserts and a deep learning model, revealing their effects on gene expression and nuclear-cytoplasmic partitioning, and highlights disease-relevant variants.

Posterior parietal cortex guides sensorimotor associative learning by linking sensation to distal action

This study identifies the rostro-lateral posterior parietal cortex as a hub that links tactile stimuli to delayed licking during sensorimotor learning, showing its role in maintaining temporal continuity through sustained activity and neural coupling.

Impact of Reduced Chlorophyll Levels in Leaves on Soybean Yield, Seed Composition, Pod/Seed Photosynthesis, and Chlorophyll Levels in Pod and Seed Tissues

Among 25 low-chlorophyll soybean mutants, a Lincoln mutant raised seed protein without yield loss, while Clark-derived Y11/y11 lowered seed oil alongside reduced pod gross photosynthesis.

FARM: Forecasting Antibiotic Resistance in Mycobacterium tuberculosis using biophysics and machine learning

The paper develops FARM, a framework to predict antibiotic resistance in Mycobacterium tuberculosis by combining biophysical and machine learning features, achieving high accuracy in distinguishing resistance-associated variants.

Human skin rejuvenation via mRNA

This paper presents a single-cell atlas of skin aging and identifies ATF3 as a regulator of aging, leading to an mRNA-based treatment that reduces cell senescence and enhances skin rejuvenation.

Diabetes-associated MYT1 and MYT3 regulate human beta-cell insulin secretion and survival via other diabetes-risk genes

This study shows MYT1 and ST18 regulate human beta-cell survival and insulin secretion under normal and stress conditions, with their genes enriched for T2D-risk loci.

Molecular architecture of OXGR1 reveals evolutionary conserved mechanisms for metabolite surveillance

This study determines the cryo-EM structures of OXGR1 bound to metabolites, revealing conserved mechanisms for metabolite recognition and receptor activation.

Ultrasensitive voltage imaging reveals distinct electrical microdomains in neurons

The paper develops a genetically encoded voltage indicator to measure subthreshold voltage dynamics in neurons, revealing electrical diversity and local computation.

Intrinsic space-time couplings governing multi-scale cortical dynamics

This study introduces a new microscopy technique to track neocortical activity with high spatial and temporal resolution, revealing fundamental dynamical elements and their properties across different neural activity regimes.

Causal and directional elements of global brain dynamics

The paper identifies directional elements in brain dynamics that encode causal control hierarchies and show robustness to neural state manipulations.

Evolution of Protein Regulation in the Vertebrate Glucose Sensor

This paper reconstructs extinct glucokinase (GCK) and glucokinase regulatory protein (GKRP) to study the evolutionary origins of protein regulation in vertebrate glucose homeostasis.

Characterization and application of hyperthermia-evoked seizures in a mouse model of focal cortical dysplasia

This study shows that hyperthermia reliably triggers seizures in a mouse model of focal cortical dysplasia, enabling testing of therapeutic interventions.

The enhanced multi-tissue atlas of regulatory effects in cattle

The paper presents CattleGTEx, a resource characterizing regulatory effects in cattle, resolving GWAS signals and providing insights into adaptive evolution and selection.

Esophageal epithelial cell-state transitions underlie the severity of pediatric eosinophilic esophagitis

The paper identifies epithelial cell-state transitions linked to disease severity in pediatric eosinophilic esophagitis using single-cell and bulk transcriptomic data.

A foundation AI model enhances electron microscopy image analysis

DF5T improves EM image quality through five tasks, enhancing segmentation and 3D restoration of organelles.

MolSpecFlow: Mass-Constrained Hybrid Flow Matching for Joint Molecular-Spectral Analysis

MolSpecFlow bridges the gap between molecules and mass spectra using a hybrid flow matching model, achieving state-of-the-art results in de novo generation and spectral simulation.

Metformin inhibits nuclear egress of chromatin fragments in senescence and aging

This study shows metformin inhibits chromatin fragment egress from the nucleus, reducing cGAS-STING activation and chronic inflammation in aging.

Cholesterol efflux protein, ABCA1, supports anti-cancer functions of myeloid immune cells

This study identifies ABCA1 as a cholesterol efflux protein that enhances anti-cancer functions of myeloid cells, with clinical relevance in breast tumors.

Computer Vision Methods for Spatial Transcriptomics: A Survey

This paper surveys computer vision methods for spatial transcriptomics, categorizing models and discussing challenges and future directions.

Mating-Type Imputation (MTI) provides an efficient tool for the mating-type inference of tetrapolar fungi

The paper introduces MTI, a software tool that efficiently infers mating types in tetrapolar fungi using a combinatorial pruning traversal algorithm, outperforming manual methods in speed and accuracy.

A lipid metabolism defect is an underlying contributor to Diamond Blackfan anemia syndrome

The paper identifies a lipid metabolism defect as a contributor to variable anemia in Diamond Blackfan anemia syndrome using a murine model and transcriptomic analysis.

Deregulated Myt3 translation predisposes islet β-cells to dysfunction under obesity-induced metabolic stress

The paper shows that Myt3 translation is deregulated in β-cells under obesity-induced stress, leading to β-cell dysfunction and glucose intolerance.

The Generalizability of Cortical Area Parcellations Across Early Childhood

This study parcellates the cerebral cortex in toddlers using functional connectivity and shows high reproducibility across ages, with area boundaries more similar to adults than neonates.

A Subset of Cortical Areas Exhibit Adult-like Functional Network Patterns in Early Childhood

This study identifies infant brain areas with adult-like functional network organization, showing less age-related variation and higher reliability, and suggests implications for using adult network models in infants.

Synergistic neuroprotective and cognitive-enhancing effects of Walnut Peptide and Theanine in human brain organoid and mouse stress models

This study shows that Walnut Peptide and Theanine reduce stress and improve cognition in human brain organoids and mice by regulating neurotransmitters and SERT/BDNF expression.

Atf4 protects islet beta-cell identity and function under acute glucose-induced stress but promotes beta-cell failure in the presence of free fatty acid

This study shows Atf4 protects beta-cell function under high glucose but worsens beta-cell failure when combined with free fatty acids.

Soleus H-Reflex Up-Conditioning during Sciatic Nerve Regeneration in Rats Improves Recovery of Locomotion

This study shows that H-reflex up-conditioning during sciatic nerve regeneration in rats improves H-reflex recovery and locomotor symmetry, while down-conditioning has no negative effect.