Cross-tissue multiomics reveals that Akkermansia muciniphila counteracts metabolic syndrome by reprograming gut microbiota, oleoylethanolamide and the gut-hypothalamus axis
Sung Min Ha, In‐Sook Ahn, Thomas Kowal, Justin G. Yoon, Christine A. Olson, Graciel Diamante, Ingrid Cely, Guanglin Zhang, Susana Wang, Karen Garcia, Zhejian Zhang, Angelus Cabanayan, Ruoshui Liu, Elaine Y. Hsiao, Xia Yang
This study identifies oleoylethanolamide (OEA) as a key mediator by which Akkermansia muciniphila alleviates fructose-induced metabolic syndrome through gut microbiota and gut-hypothalamus axis modulation.
bioRxiv · Sep 6, 2022 · PreprintSystems Biology